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In clinical trials of new medicines, half of the subjects

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SVP
SVP
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Joined: 30 Oct 2003
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In clinical trials of new medicines, half of the subjects [#permalink] New post 31 Dec 2003, 13:40
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18. In clinical trials of new medicines, half of the subjects receive the drug being tested and half receive a physiologically inert substance ?a placebo. Trials are designed with the intention that neither subjects nor experimenters will find out which subjects are actually being given the drug being tested. However, this intention is frequently frustrated because ____.

Which one of the following, if true, most appropriately completes the explanation?

(A) often the subjects who receive the drug being tested develop symptoms that the experimenters recognize as side effects of the physiologically active drug

(B) subjects who believe they are receiving the drug being tested often display improvements in their conditions regardless of whether what is administered to them is physiologically active or not

(C) in general, when the trial is intended to establish the experimental drug's safety rather than its effectiveness, all of the subjects are healthy

(D) when a trial runs a long time, few of the experimenters will work on it from inception to conclusion

(E) the people who are subjects for clinical trials must, by law, be volunteers and must be informed of the possibility that they will receive a placebo
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 [#permalink] New post 31 Dec 2003, 15:15
I will go with A.
Though B seems to be close
SVP
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 [#permalink] New post 31 Dec 2003, 15:39
Correct answer is A. I chose B. If you guys have time please justify your answers. Your reasoning ( right or wrong ) will definitely help me and others.
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Senior Manager
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 [#permalink] New post 31 Dec 2003, 15:57
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Trials are designed with the intention that neither subjects nor experimenters will find out which subjects are actually being given the drug being tested.

As per the expectation either the subjects or the experimenters should know who has been given the drug. But the experimenters come to know because of the side effects.
SVP
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Joined: 30 Oct 2003
Posts: 1798
Location: NewJersey USA
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Kudos [?]: 36 [0], given: 0

 [#permalink] New post 31 Dec 2003, 16:08
Hats off to you. Unbelievable reasoning. Fantastic explaination indeed.
  [#permalink] 31 Dec 2003, 16:08
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