You've worked at great companies and it's great that you have a business/sales background professionally vs. an IT background. Your current extracurricular and community experience is limited and does not demonstrate strong leadership capacity. However, if you can spin your healthcare software into an entrepreneurial experience, that could go a long way. Still, with a 650 GMAT and your academic profile, I think ISB would be a reach. Perhaps if you scored above a 700 (ideally closer to 750), this could become more realistic.
Without knowing your GMAT, it's difficult to say where exactly you should target. Let's assume you score a 650, then you could target schools like Emory, Michigan State, Georgetown, Tulane. If you score a 700, you could aim a little higher. Same goes for the UK schools - you'll aim lower if your GMAT score is in the 650 range and higher if you can achieve a 700+ (LBS) would still be a reach, but it's within the realm of possibility with a very high GMAT score).
Unfortunately, I can't provide an answer to your last question. School costs, costs of living, and expected salaries from each vary greatly and depend on what job you'll get and in which country, etc. You'll have to think through whether these programs are worth it to you and do your own cost/benefit analysis based on your personal goals, priorities and constraints.
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