Sometimes this is a meaning issue. Are you making sure that the choice you have selected makes sense in the context of the sentence? Does it distort the intended meaning?
Other times, it is simply a matter of spotting additional splits and choosing the issue you feel best qualified to address. If an option just "doesn't sound right," delay that decision and try to find an issue you feel more sure about. After your time is up, spend additional time reviewing each question BEFORE checking the answer. Try to identify for yourself why each choice is right or wrong, and try to make decisions on any issues you didn't use in selecting an answer. (E.g. if you crossed off B due to parallelism, look at the rest of it and see what you think about the other issues it raises).
Then, once you feel as solid as possible about why each choice is right or wrong, check the answer and explanation and see how well it matches with your reasoning. If you missed the problem, spend some serious time identifying which issues you failed to identify, or chose the wrong side on. Take that tempting wrong answer and do your best to smash it. You don't just want to say "Oh, C is a better choice." You want to be able to say "E is incorrect and here are the reasons." If the explanation in the Official Guide is inadequate (this is not unlikely), look the problem up in the forums.
If you get really good at this work, starting with timed problems and following through with very thorough untimed review, you should become a faster and more attentive test-taker, and you will have more time and attention to focus on distinguishing the fine shades of meaning that this test sometimes requires. Good luck!
Dmitry Farber | Manhattan GMAT Instructor | New York
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