Several genes have been acknowledged
that appear to play a role in the advance of
obesity. These genes are often identified
through mouse models for obesity, such as a
5 pure-breeding strain of obese mice called
Rotund. The behavior of Rotund mice
includes increased food consumption and
body weight, and decreased body
temperature and activity. When injected
10 with blood from normal animals, Rotund
mice exhibit a momentary decrease in food
intake. This information suggests that a
secreted factor that signals satiety exists,
turning off the desire for food in normal
15 animals when energy reserves in stock tissue
are sufficient.
When the gene responsible for the
Rotund behavior was identified, it was
found to encode a protein secreted from
20 adipocytes in normal mice. This protein was
termed the rotund protein.
Injection of purified rotund protein from
wild-type mice into Rotund mice induces a
decrease in food intake, an increase in body
25 temperature, an increase in activity, and a
decrease over several weeks in the ratio of
energy stock tissue to skeletal muscle.
Control injections lacking rotund protein did
not produce these changes. Also, injection
30 of rotund protein into normal mice does not
alter weight or other parameters of mouse
physiology, indicating that the weight loss in
Rotund mice is not caused by toxicity of the
protein to the animal.
35 Although the research on the rotund
protein and on its effects on obesity is in its
development phase, scientists hope that what
they learn from these experiments with mice
will shed some light on the ongoing research
40 on human obesity.


Which of the following can be most strongly inferred from the passage?

i) Humans have similar proteins to those of Rotund mice.
ii)Rotund mice have heart failure problems.
iii) Rotund proteins from wild-type mice and pure-breeding mice do not have the same effect.
iv) Rotund protein does not have any toxic effects on the Rotund mice.
v) Researchers need more fiscal leeway with their important research on obesity.

When injected with blood from normal animals, Rotund
mice exhibit a momentary decrease in food
intake.
Injection of purified rotund protein from
wild-type mice into Rotund mice induces a
decrease in food intake, an increase in body
25 temperature, an increase in activity, and a
decrease over several weeks in the ratio of
energy stock tissue to skeletal muscle.

c

Sanjay, Please post the OA.

Picked A, but then changed it to C.


Damn this is too close. Please post the damn OA????