First things first. Know what relative pronoun means.
Relative pronouns are pronouns which introduce a relative clause which says more abt the noun or in other words its antecendent. Examples of relative pronoun are "that", "which", "who", "whoom",etc.
Now always remember relative pronouns are placed as close to the antecedent as possible. If that is not the case then the whole meaning gets distorted.
Consider this...
Rob has a dog
whose name is tommy.
Now whose is a relative clause. So, whose clearly refers to its antecedent dog.
Consider this..
Rob's dog met with an accident
whose name is tommy.
Now, you see the antecedent of whose is
accident and not dog.
So the meaning of the sentence is totally distorted and hence you leanr one thing always have the relative pronoun placed as close as possible to the antecedent.
Now your example
Curly05 wrote:
I thought the subject here refers to (one ) and the verb should be ( tells) . But apparently, the subject is (substances) and (tells) is the verb.
Is it because both can tell individual genes what to do.
VT
One of the
substances that tell individual genes.
So from our rule which we leanrt above, we know that refers to it antecedent substances and not ONE.
So verb will be plural and that is "tell" in this case.
HTH!!!