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The sensation of pain cannot accurately be described as
[#permalink]
09 Nov 2010, 22:38
The sensation of pain cannot accurately be described as “located” at the point of an injury, or, for that matter, in any one place in the nerves or brain. Rather, pain signals—and pain relief—are delivered through a highly complex interacting circuitry. When a cell is injured, a rush of prostaglandins sensitizes nerve endings at the injury. Prostaglandins are chemicals produced in and released from virtually all mammalian cells when they are injured: these are the only pain signals that do not originate in the nervous system. Aspirin and other similar drugs (such as indomethacin and ibuprofen) keep prostaglandins from being made by interfering with an enzyme known as prostaglandin synthetase, or cyclooxygenase. The drugs’ effectiveness against pain is proportional to their success in blocking this enzyme at the site of injury. From nerve endings at the injury, pain signals move to nerves feeding into the spinal cord. The long, tubular membranes of nerve cells carry electrical impulses. When electrical impulses get to the spinal cord, a pain-signaling chemical known as substance P is released there. Substance P then excites nearby neurons to send impulses to the brain. Local anesthetics such as novocaine and xylocaine work by blocking the electrical transmission along nerves in a particular area. They inhibit the flow of sodium ions through the membranes, making the nerves electrically quiescent; thus no pain signals are sent to the spinal cord or to the brain. Recent discoveries in the study of pain have involved the brain itself—the supervising organ that notices pain signals and that sends messages down to the spinal cord to regulate incoming pain traffic. Endorphins—the brain’s own morphine—are a class of small peptides that help to block pain signals within the brain itself. The presence of endorphins may also help to explain differences in response to pain signals, since individuals seem to differ in their ability to produce endorphins. It now appears that a number of techniques for blocking chronic pain—such as acupuncture and electrical stimulation of the central brain stem—involve the release of endorphins in the brain and spinal cord
1. The passage is primarily concerned with (A) analyzing ways that enzymes and other chemicals influence how the body feels pain (B) describing the presence of endorphins in the brain and discussing ways the body blocks pain within the brain itself (C) describing how pain signals are conveyed in the body and discussing ways in which the pain signals can be blocked (D) demonstrating that pain can be influenced by acupuncture and electrical stimulation of the central brain stem (E) differentiating the kinds of pain that occur at different points in the body’s nervous system 2. According to the passage, which of the following is one of the first things to occur when cells are injured? (A) The flow of electrical impulses through nerve cells at the site of the injury is broken. (B) The production of substance P traveling through nerve cells to the brain increases. (C) Endorphins begin to speed up the response of nerve cells at the site of the injury. (D) A flood of prostaglandins sensitizes nerve endings at the site of the injury. (E) Nerve cells connected to the spinal cord become electrically quiescent. 3. Of the following, which is most likely attributable to the effect of endorphins as described in the passage? (A) After an injection of novocaine, a patient has no feeling in the area where the injection was given.
(B) After taking ibuprofen, a person with a headache gets quick relief. (C) After receiving a local anesthetic, an injured person reports relief in the anesthetized area. (D) After being given aspirin, a child with a badly scraped elbow feels better. (E) After acupuncture, a patient with chronic back pain reports that the pain is much less severe. 4. It can be inferred from the passage that if the prostaglandin synthetase is only partially blocked, which of the following is likely to be true? (A) Some endorphins will be produced, and some pain signals will be intensified. (B) Some substance P is likely to be produced, so some pain signals will reach the brain. (C) Some sodium ions will be blocked, so some pain signals will not reach the brain. (D) Some prostaglandins will be produced, but production of substance P will be prevented. (E) Some peptides in the brain will receive pain signals and begin to regulate incoming pain traffic.
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Re: The sensation of pain cannot accurately be described as
[#permalink]
22 Nov 2010, 08:03
anilnandyala wrote:
The sensation of pain cannot accurately be described as “located” at the point of an injury, or, for that matter, in any one place in the nerves or brain. Rather, pain signals—and pain relief—are delivered through a highly complex interacting circuitry. When a cell is injured, a rush of prostaglandins sensitizes nerve endings at the injury. Prostaglandins are chemicals produced in and released from virtually all mammalian cells when they are injured: these are the only pain signals that do not originate in the nervous system. Aspirin and other similar drugs (such as indomethacin and ibuprofen) keep prostaglandins from being made by interfering with an enzyme known as prostaglandin synthetase, or cyclooxygenase. The drugs’ effectiveness against pain is proportional to their success in blocking this enzyme at the site of injury. From nerve endings at the injury, pain signals move to nerves feeding into the spinal cord. The long, tubular membranes of nerve cells carry electrical impulses. When electrical impulses get to the spinal cord, a pain-signaling chemical known as substance P is released there. Substance P then excites nearby neurons to send impulses to the brain. Local anesthetics such as novocaine and xylocaine work by blocking the electrical transmission along nerves in a particular area. They inhibit the flow of sodium ions through the membranes, making the nerves electrically quiescent; thus no pain signals are sent to the spinal cord or to the brain. Recent discoveries in the study of pain have involved the brain itself—the supervising organ that notices pain signals and that sends messages down to the spinal cord to regulate incoming pain traffic. Endorphins—the brain’s own morphine—are a class of small peptides that help to block pain signals within the brain itself. The presence of endorphins may also help to explain differences in response to pain signals, since individuals seem to differ in their ability to produce endorphins. It now appears that a number of techniques for blocking chronic pain—such as acupuncture and electrical stimulation of the central brain stem—involve the release of endorphins in the brain and spinal cord
1. The passage is primarily concerned with (A) analyzing ways that enzymes and other chemicals influence how the body feels pain Pretty close (B) describing the presence of endorphins in the brain and discussing ways the body blocks pain within the brain itself this is discussed only in the end (C) describing how pain signals are conveyed in the body and discussing ways in which the pain signals can be blocked This is it (D) demonstrating that pain can be influenced by acupuncture and electrical stimulation of the central brain stem Same as B (E) differentiating the kinds of pain that occur at different points in the body’s nervous system No Differentiation is spoken about in the passage 2. According to the passage, which of the following is one of the first things to occur when cells are injured? (A) The flow of electrical impulses through nerve cells at the site of the injury is broken. _ Funny then no one will feel pain (B) The production of substance P traveling through nerve cells to the brain increases. P is second and is only activated by prostaglandins (C) Endorphins begin to speed up the response of nerve cells at the site of the injury. - Endorphins are brains morphine,s its our friend (D) A flood of prostaglandins sensitizes nerve endings at the site of the injury.Here we go from the end of the last Para (E) Nerve cells connected to the spinal cord become electrically quiescent. Spinal cord is second spot 3. Of the following, which is most likely attributable to the effect of endorphins as described in the passage? (A) After an injection of novocaine, a patient has no feeling in the area where the injection was given.
(B) After taking ibuprofen, a person with a headache gets quick relief. (C) After receiving a local anesthetic, an injured person reports relief in the anesthetized area. (D) After being given aspirin, a child with a badly scraped elbow feels better. (E) After acupuncture, a patient with chronic back pain reports that the pain is much less severe. Spoken in relation to endorphins 4. It can be inferred from the passage that if the prostaglandin synthetase is only partially blocked, which of the following is likely to be true? (A) Some endorphins will be produced, and some pain signals will be intensified. (B) Some substance P is likely to be produced, so some pain signals will reach the brain. (C) Some sodium ions will be blocked, so some pain signals will not reach the brain. (D) Some prostaglandins will be produced, but production of substance P will be prevented. (E) Some peptides in the brain will receive pain signals and begin to regulate incoming pain traffic.Peptides doesnt recieve signal. Its the BRAIN
Re: The sensation of pain cannot accurately be described as
[#permalink]
10 Dec 2010, 08:34
I got C, D, E, D. I didn't see the part in the question where it says "if the prostaglandin synthetase is only partially blocked" in #4. (I saw it I just didn't pay that much attention to it.) so i answered D but the right ans it definitely B.
Re: The sensation of pain cannot accurately be described as
[#permalink]
05 May 2012, 03:41
I am a little confused with the Answer for Question 4. I feel C should be the correct answer. According to the passage:
prostaglandins : "....these are the only pain signals that do not originate in the nervous system" Substance P originates in Spinal chord ( part of nervous system).
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Re: The sensation of pain cannot accurately be described as [#permalink]