E is clearly the best answer
I rephrased the second sentence of the stem and also rephrased E:
Most [artists] hold political views that are less insightful than those of any reasonably well-educated person who is not an artist
E) Some artists are at least as insightful
as some reasonably well-educated persons who are not artists
As you can see, rephrased as such, E is clearly the best option. When you have comparative forms, make sure you can rephrase those convoluted phrases so as to be in a better position to compare them with the stem. Also, tweak the stem if you need to.
D is misleading at best. We know that artists have little insights into politics. This in no way means that politicians have no artistic talents. It is like saying that only a small number of mushrooms are venimous and then conclude that venimous things are rarely mushrooms. This may be wrong if mushrooms comprise 90% of venimous things.