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Mice treated with certain statins intended to decrease blood pressure

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Mice treated with certain statins intended to decrease blood pressure  [#permalink]

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New post 26 Jul 2018, 20:09
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Mice treated with certain statins intended to decrease blood pressure also experienced drug-induced toxic myopathy, also known as muscular degeneration. Scientists hypothesize that this may have occurred because the statins cause an over-activation of creatine kinases, which are known to cause muscular degeneration.

Which of the following experiments would yield the most useful results for analyzing the scientists’ hypothesis?


A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.

B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response.

C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response.

D. Injecting mice with muscle repair medication and then monitoring levels of muscular response.

E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more

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Re: Mice treated with certain statins intended to decrease blood pressure  [#permalink]

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New post 26 Jul 2018, 20:47
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Bunuel wrote:
Mice treated with certain statins intended to decrease blood pressure also experienced drug-induced toxic myopathy, also known as muscular degeneration. Scientists hypothesize that this may have occurred because the statins cause an over-activation of creatine kinases, which are known to cause muscular degeneration.

Which of the following experiments would yield the most useful results for analyzing the scientists’ hypothesis?


A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.

B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response.

C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response.

D. Injecting mice with muscle repair medication and then monitoring levels of muscular response.

E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more


+1 for B

Prethinking:
As per scientists hypothesis we need to find a way by which we can prove that creatine kinases causes muscle degeneration.

A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.
-Incorrect. Statins can have other factors too so only increasing creatine kinase activity can't prove whether creatine kinase is the only reason for muscle degenration.
B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response.
- Correct. This gives us a clear picture when you use creatine kinase inhibitor and monitor muscle tissue response then if the muscle tissue degeneration slows down then we get the answer to our question. If it doesn't then we get the answer to our question.
C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response.
-Incorrect. The difference between B and C is C tells us to use multiple creatine kinase inhibitors which may give varying response and it also doesn't mention when to inject i.e., before administering statins or after.
D. Injecting mice with muscle repair medication and then monitoring levels of muscular response.
-Incorrect. Out of scope
E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more
-Incorrect. Out of scope
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Re: Mice treated with certain statins intended to decrease blood pressure  [#permalink]

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New post 26 Jul 2018, 20:56
+1 for B

Injecting inhibitor before statins and thereafter, observations after statins injection can conclude the hypothesis.

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Mice treated with certain statins intended to decrease blood pressure  [#permalink]

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New post 26 Jul 2018, 21:02
Mice treated with certain statins intended to decrease blood pressure also experienced drug-induced toxic myopathy, also known as muscular degeneration. Scientists hypothesize that this may have occurred because the statins cause an over-activation of creatine kinases, which are known to cause muscular degeneration.

Which of the following experiments would yield the most useful results for analyzing the scientists’ hypothesis?


A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.

B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response. we can see whether the mice experienced myopathy. If yes, then statins don't cause M.G. If no, statins cause M.G

C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response. this excludes statins, an integral part to draw a conclusion.

D. Injecting mice with muscle repair medication and then monitoring levels of muscular response. this excludes statins, an integral part to draw a conclusion.

E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more - this excludes statins, an integral part to draw a conclusion.
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Re: Mice treated with certain statins intended to decrease blood pressure  [#permalink]

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New post 30 Jul 2018, 01:14
1
Bunuel wrote:
Mice treated with certain statins intended to decrease blood pressure also experienced drug-induced toxic myopathy, also known as muscular degeneration. Scientists hypothesize that this may have occurred because the statins cause an over-activation of creatine kinases, which are known to cause muscular degeneration.

Which of the following experiments would yield the most useful results for analyzing the scientists’ hypothesis?


A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.

B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response.

C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response.

D. Injecting mice with muscle repair medication and then monitoring levels of muscular response.

E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more


VERITAS PREP OFFICIAL SOLUTION:



When you are asked to determine which experiment would yield useful results for analyzing a particular problem, recognize that this means that you are dealing with a (slightly less obvious) Useful to Evaluate problem. With any Useful to Evaluate problem, remember that you first want to look at the stimulus itself to figure out what the scientists or analysts are trying to determine. Then look for the gap - what piece of information is missing that could potentially either prove their hypothesis or disprove it?

The stimulus states that mice treated with statins experienced drug-induced muscular degeneration and that the scientists think this might have been cause by the statins over-activating something called creatine kinase (which is known to cause muscular degeneration). Notice that the hypothesis has to do with cause and effect: statins cause an over-activation of creatine kinase, which causes muscular degeneration. But what if the statins directly caused the degeneration instead of causing that intermediate step? Choice (B) is the only option that accounts for this possibility. By first administering a creatine kinase blocker, scientists can ensure that the effect is caused because the statins activate the creatine kinase rather than because the statins directly damage muscles. Choice (B) is therefore correct.

Among the other answers, choices (A) and (D) can be eliminated because they don't mention creatine kinase at all. Choice (C) can be eliminated because it doesn't mention the administering the statin. Since you're looking for the mechanism by which the statin causes muscular degeneration. Choice (E) can be eliminated because it's already known that creatine kinase can cause muscular myopathy - you don't need to establish that again, so (E) can be eliminated.
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Resources:
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Collection of Questions:
PS: 1. Tough and Tricky questions; 2. Hard questions; 3. Hard questions part 2; 4. Standard deviation; 5. Tough Problem Solving Questions With Solutions; 6. Probability and Combinations Questions With Solutions; 7 Tough and tricky exponents and roots questions; 8 12 Easy Pieces (or not?); 9 Bakers' Dozen; 10 Algebra set. ,11 Mixed Questions, 12 Fresh Meat

DS: 1. DS tough questions; 2. DS tough questions part 2; 3. DS tough questions part 3; 4. DS Standard deviation; 5. Inequalities; 6. 700+ GMAT Data Sufficiency Questions With Explanations; 7 Tough and tricky exponents and roots questions; 8 The Discreet Charm of the DS; 9 Devil's Dozen!!!; 10 Number Properties set., 11 New DS set.


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Re: Mice treated with certain statins intended to decrease blood pressure  [#permalink]

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New post 09 Aug 2018, 17:36
Bunuel wrote:
Mice treated with certain statins intended to decrease blood pressure also experienced drug-induced toxic myopathy, also known as muscular degeneration. Scientists hypothesize that this may have occurred because the statins cause an over-activation of creatine kinases, which are known to cause muscular degeneration.

Which of the following experiments would yield the most useful results for analyzing the scientists’ hypothesis?


A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.

B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response.

C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response.

D. Injecting mice with muscle repair medication and then monitoring levels of muscular response.

E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more


My choice is B as it is providing clear cut helps to evaluate the scientists' hypothesis.
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Re: Mice treated with certain statins intended to decrease blood pressure &nbs [#permalink] 09 Aug 2018, 17:36
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