Although crime fiction novelist Agatha Christie’s two most popular det

There are issues with pronouns.
I don't quite believe '...novelist Agatha Christie's ...' is wrong per se. So may be one of the experts could weigh in on that.

Here is what I see

A. 'She' needs to have an antecedent that is specifically mentioned in the text. The next has A.C's characters and not A.C., So there is a missing antecedent issue.
B. This, for me changed the meaning of the sentence. It makes two clauses detached. There is not linking ground because there is no reference to A.C. in the second clause.
C. 'Who' is clearly wrong again, it seems to modify Jane Marple. And if not, then There is no A.C. in the text and hence no antecedent.
D. No issues, who modifies A.C. perfectly.
E. There is no use for the word 'Despite'. I also don't like the word 'being' here. The modification does not look right.