Although, Though, Despite and Inspite

Sure.

"Although" and "though" are completely interchangable. There are no exceptions to this rule that I am aware of. "Although" is slightly more common.

"Although the Red Wings are by far the nation's favorite hockey team, a trip to Denver reminds them that not everyone loves them."

"Though JP no longer lives in Michigan, he likes the Red Wings."

"Despite" is similar, but cannot stand on its own. It needs a subject so that it can be part of a complete sentence. For example:

"Despite the fact that the Red Wings lost, they are the better team."
"Despite my reluctance to admit it, the Red Wings sometimes lose."

"Inspite" is not a word, but "In spite of" is a phrase. This phrase is completely interchangable with "despite."

Hope this helps.[/b]