I'm a consultant so after some undesirable cube or conference room the client forked over, my laptop bag is the closest thing I have to an office. Which would partially explain why I've tried so many different bags over the years (the remainder is just me liking bags and gadgets).
Here's my top 4 in reverse order:
4. Booq - had an older model laptop backpack, not bad at all. Not as durable as those that follows--some good ideas, but sort of flimsy construction and more neat than trusty.
https://www.booqbags.com/ 3. Brenthaven - I have a leather one and a ballistic one. I wish I hadn't bought the leather one, it wasn't as nice as I'd hoped and it was expensive (and now gathers dusk to my #1s below).
https://www.brenthaven.com/catalog-cyc-leather-sc.html2. Crumpler - everything they make is awesome. Well put together, extremely durable and innovative. I have a laptop backpack and a messenger bag. Both are a little colorful for work, so they're for casual use only, but they're some of my favorite bags otherwise.
https://www.crumplerbags.com1. Tom Bihn - I have an Empire Builder and a matching Zephyr. I find myself taking both on the road with me more often than not. These bags are well thought out and amazingly built. They have a ton of nice little touches and features and they're deceptively large. I also love that they're conservative enough for my job but they're not as boring as the Cobi and Tumi's everyone else totes around. (Btw, both of those brands suck for what you pay... they do not last and zero ergonomics, relatively speaking.) I love Tom Bihn and Crumpler, for my money (and I've put way too much of it where my mouth is in this department) they're worth the incremental dollars if you live on the road and need your bag to work hard for you.
https://www.tombihn.com/page/001/PROD/300/TB0730