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SolankiDas
"once considered" is past event -1
and "had brains" is another past event-2 happened before past event -1
so, past perfect is used. right?

Infinitives ("to + VERB") are not verbs, so they don't have verb tenses.

Infinitives are modifiers. Like other modifiers that don't contain verbs, they indicate timeframes RELATIVE TO the clause to which they're attached.
• "to + VERB" adopts the SAME timeframe as the clause to which it's attached.
• "to + have VERBed" indicates a timeframe PRIOR TO that of the clause to which it's attached.

The actual VERB here is "ARE known"—which must appear in the present tense, because this is something that anthropologists KNOW ••NOW•• (in the present timeframe).

Given THAT TENSE:
• "to + HAVE" is INCORRECT. This infinitive must adopt the same timeframe as the clause to which it's attached—but that's nonsense here, because the timeframe of that clause is the present. Neanderthals do not exist anymore (they were driven to extinction by early humans).
• "to + have HAD" is CORRECT. This infinitive indicates a PRIOR timeframe—so, in this case, it signals something from EARLIER THAN THE PRESENT. That's exactly what we need.
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