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Hi MartyMurray, although I got why A is correct, but I have some issue with C and with E. Can you please help? If there are other genes apart from BRCA1 and BRCA2, linked to breast cancer, then in any case one need to do mammogram. For example, lets suppose one used genetic testing and it was found out that she doesn't have BRCA1 and BRCA2, but to check if she has breast cancer for some other reason (maybe some other gene that is linked to breast cancer) one needs to do mammogram. In another case if one did genetic testing and found out the presence of BRCA1 and BRCA2, one would still prefer to do mammogram as genetic testing confirms only the presence of those two genes linked to breast cancer, but doesn't say patient has breast cancer or not. So in both the cases, percentage of women taking mammogram tests might not decline. In explanations, I have read this option is irrelevant and one should eliminate, can you help me see how?

(C) Aside from BRCA1 and BRCA2, there are no other genes that are strongly linked to breast cancer.
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Two genes, BRCA1 and BRCA2, are linked to hereditary breast cancer. Genetic testing, which can detect these genes, is increasing in both accuracy and prevalence. The test is also less painful and invasive than a mammogram, which is typically used to detect early signs of breast cancer. Therefore, we can expect the percentage of women who undergo mammograms each year to decrease.

Which of the following is an assumption on which the argument depends?


The argument says genetic testing for BRCA1 and BRCA2 is becoming more accurate and more common, and since it is less painful and less invasive than a mammogram, the percentage of women getting mammograms will decrease. The key assumption is that at least some women will use the genetic test instead of a mammogram. Without that link, the fact that the test is easier would not show that mammogram use will fall.

(A) Some women who are tested for BRCA1 and BRCA2 will choose not to undergo a mammogram.

This is the correct answer. The conclusion that mammogram rates will decrease depends on at least some women substituting the genetic test for a mammogram. If all women who get the genetic test still get mammograms anyway, then mammogram use would not necessarily decrease.

(B) The percentage of women undergoing mammograms each year has remained consistent over the last decade.

This is not required. The argument is about what will happen in the future, not about whether mammogram rates were stable in the past.

(C) Aside from BRCA1 and BRCA2, there are no other genes that are strongly linked to breast cancer.

This is not needed. Even if there are other genes, the argument could still work as long as some women skip mammograms because of BRCA testing.

(D) Doctors will continue to recommend regular mammograms for all women at risk of breast cancer, regardless of the results of genetic testing.

This actually goes against the conclusion. If doctors continue recommending mammograms for all at-risk women no matter what the genetic test shows, then mammogram rates may not decrease.

(E) A significant percentage of cases of breast cancer are linked to BRCA1 or BRCA2.

This strengthens the argument, but it is not necessary. The conclusion only needs some substitution away from mammograms, not that BRCA1 and BRCA2 explain a large share of all breast cancer cases.

Answer: (A)
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