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Option A only logically gives questionable reasoning. Option C does not clearlly states what it is trying to say. So answer is Option A.
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A. Treats as similar two cases that are different in a critical respect

Sure, environmentalists treat two cases of affecting the ozone layer, omitting a critical respect, the goals of each one.

C. Fails to distinguish the goal of reversing harmful effects from preventing those harmful effects

The environmentalists think that is unjustifiable to do damage to the ozone layer, this is what really matters for them, so it is not really that they fail to distinguish the goal of the experiment but that they did not even consider the experiments possible to do given that it is doing harm to the ozone layer. Incorrect
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Scientists hoping to understand and eventually reverse damage to the fragile ozone layer in the Earth's upper atmosphere used a spacecraft to conduct crucial experiments. These experiments drew criticism from a group of environmentalists who observed that a single trip by the spacecraft did as much harm to the ozone layer as a year's pollution by the average factory, and that since the latter was unjustifiable so must be the former.

The reasoning in the environmentalists' criticism is questionable because it:

A. Treats as similar two cases that are different in a critical respect
B. Justifies generalization on the basis of a single instance
C. Fails to distinguish the goal of reversing harmful effects from preventing those harmful effects
D. Attempts to compare two quantities that are not comparable in any way
E. Presupposes that experiments always do harm to their subjects

Options A and C are the two contenders.

C. Fails to distinguish the goal of reversing harmful effects from preventing those harmful effects
How could we say that the environmentalists have failed to distinguish the GOAL of reversing harmful effects from preventing those harmful effects? They know the goal of the space mission; Their argument is that it is comparable to the factory with respect to the pollution it created.

A. Treats as similar two cases that are different in a critical respect
Correct choice. The space mission will collect crucial data that will help the scientists; a factory will only create the problem they are trying to solve.
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KarishmaB GMATNinja AndrewN
Please help me in understanding Why A is better than C?­
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Sans8
KarishmaB GMATNinja AndrewN
Please help me in understanding Why A is better than C?­
­The flaw in C is that it presupposes that the goal of the spacecraft is to reverse the ozone damage. But that's not the case here, the goal was to "understand the damage", so that's why C got it wrong. If you read closely, the flaw resides in the assumption that the nature of both aircraft survey and factory is same. Two cases, though both damage ozone, are critically different. One is to "understand the ozone depletion", whereas the other is not concerned with the depletion in any whatsoever. Thus different in critical respect. 
Hope it helps.
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