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Trainer: Research shows that when dogs are neutered in early puppyhood, their leg bones usually do not develop properly. Improper bone development leads in turn to problems with arthritis as dogs grow older. Thus, if you want to protect your dog from arthritis you should not neuter your dog until it is full-grown.

Of the following, which one is a criticism to which the reasoning in the trainer’s argument is most vulnerable?

(A) It fails to state exactly what percentage of dogs neutered in early puppyhood experience improper bone development. Incorrect

this choice somehow contradicts with argument, if less percentage percentage of dogs neutered in early puppyhood experience improper bone development than it weakens argument

(B) It fails to explain the connection between improper bone development and arthritis. Incorrect

already know improper bone development leads arthritis

(C) It fails to address the effects of neutering in middle or late puppyhood. Incorrect

effects of neutering in middle or late puppyhood are irrelevant to argument

(D) It fails to consider the possibility that the benefits of neutering a dog early might outweigh the risk of arthritis. Incorrect

dont know there are benefits of neutering during a dog's early puppyhood

(E) It fails to consider the possibility that dogs with properly developed bones can develop arthritis. Correct

author ignore this choice in last line of the argument. a dog can develop arthritis without neutered in early puppyhood
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We need to find one evidence that would weaken the argument the most.

(A) It fails to state exactly what percentage of dogs neutered in early puppyhood experience improper bone development.
This information does not matter and does not weaken the argument or expose the flaw in trainer's argument. Eliminate

(B) It fails to explain the connection between improper bone development and arthritis.
This does find fault with neutering the dogs. Eliminate

(C) It fails to address the effects of neutering in middle or late puppyhood.
Yes, the argument explains about problem with neutering with early puppyhood. It is possible that neutering the dogs in their later part of their life may also lead health conditions. Hence, this weakens the most among all other choices. Hence C is the right choice.

(D) It fails to consider the possibility that the benefits of neutering a dog early might outweigh the risk of arthritis.
This only strengthens the argument, but we are looking for the one that can weaken the argument, the most. Eliminate

(E) It fails to consider the possibility that dogs with properly developed bones can develop arthritis.
The argument presented only about the early neutering effect lead to arthritis. It does not consider the other phenomena.
Eliminate.
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The argument is similar to this one: You shouldn't study for the GMAT five years before your test, because you might forget everything by the time you take your test. Therefore you should wait until the day before your test to study. That's obviously a bad argument because it ignores the possibility of studying three months before the test, say.

The same is true of this dog argument: the evidence is only about "early puppyhood" and the conclusion says you should wait until dogs are "full-grown". The argument ignores the middle and late puppyhood periods altogether, so C is the right answer.
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