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In this case, the units digit and the tens digit of a product is the units and tens digit of the product of the units digits being multiplied.

That does turn out to be true in this particular case, but in general, if you want to predict the tens digit of a product, you need to take account of both the tens and the units digits of the numbers you're multiplying together. For example, 121 = 11*11, and we can't guess that 11*11 will end in '21' by considering units digits alone.

But in this particular question, we don't even need to consider tens digits. Our units digits are the distinct digits Q and R, and we're getting a product ending in '1'. If Q and R are different, they can only be 3 and 7, since those are the only distinct one-digit numbers with a product ending in 1. Since P is clearly 1 here (if P were 2 or greater, both two-digit numbers would be greater than 20, and their product would be greater than 400), the answer must be 1+3+7 = 11.

Or you can notice that 221 = 225 - 4 = 15^2 - 2^2 = (15+2)(15-2) = 17*13, and arrive at the values of P, Q and R that way (in some order -- we can't tell which of Q or R is 3 and which is 7, but that's not important here).

Or I suppose once you notice P = 1, you can then tell that the sum must be somewhere between 1+3+5 and 1+7+9, since the other two digits must be odd and distinct, and that means only two answer choices B and C are even plausible, and then it's not too time-consuming to test the various possibilities. But that seems the slowest approach here.
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We need to find distinct digits P, Q, and R such that the product of the two-digit integers PQ and PR equals 221.

First, notice that 221 = 13 × 17, which means PQ could be 13 and PR could be 17 (or vice versa). The common digit P in both numbers must be 1, while Q is 3 and R is 7.

Thus, the sum of the digits P, Q, and R is 1 + 3 + 7 = 11.

Answer: B (11)
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