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# Estrogen alone increases the risk of uterine cancer and of

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Estrogen alone increases the risk of uterine cancer and of [#permalink]

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01 Apr 2004, 06:54
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1.Estrogen alone increases the risk of uterine cancer and of breast cancer. Estrogen combined with the progestin does not increase the
risk of uterine cancer; this combination does cause the same increase
in risk for the breast cancer as does estrogen alone.
If the above information is correct , which of the following would be
an expected result?

a. More women taking estrogen alone will develop uterine cancer than
breast cancer.
b. Fewer women taking neither estrogen nor progestin will develop
uterine cancer than women taking estrogen and progestin.
c. more women taking estrogen alone will develop breast cancer than
women taking estrogen and progestin.
d. Fewer women taking only progestin will develop uterine cancer than
women taking estrogen and progestin.
e. The same percentage of women taking estrogen and progestin will
develop uterine cancer as women taking neither estrogen nor progestin.
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01 Apr 2004, 08:07
Boiled down to D and E but E wins!
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01 Apr 2004, 08:10
I will go with C on this one.

A ) not correct because effect of estrogen on breast cancer and uterine cancer is not compared individually

B) This also cannot be infered because combination of the two drugs reduces the risk but no comparision w.r.to those not taking is given

C) is the most reasonable - as the stem says combinations does not result in the same increase of risk ( well this can be refuted - may be the risk is more )

D) No effect or progetrin alone is described

E) We dont know this. Not taking progestin might increase the chances of any one cancer.
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01 Apr 2004, 08:31
anand C is wrong as the stem states
this combination (Estrogen + Progestin) does cause the same increase
in risk for the breast cancer as does estrogen alone

Rgds,
batli
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01 Apr 2004, 08:43
Then only B stands out.

Because all that the stem says is progestin neither reduces nor increases the chance of uterine cancer. Since estrogen increases the risk then women who dont take it are less vulnerable than those who take it.
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01 Apr 2004, 08:46
I spent the last 20 min trying to negate C but I realized that my reasoning was flawed. Yes, C is it
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01 Apr 2004, 08:55
Paul and Anandnk,
I need a bit of clarification on C

The stem says that Estrogen alone increases the risk of breast cancer. Again Estrogen and Progestin cause the same increase in risk as does estrogen alone.

This means whe have two groups A and B.
A takes estrogen alone.
B takes estrogen + progestin.

But the increase in risk in both the groups are same.

In that case, how can we say that C is the result.

Am I missing anything?
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01 Apr 2004, 08:56
the risk should be same and not fewer as given in choice B.
E+P does not increase the risk of Uterine cancer in women as good as not taking E or P.

rgds,
batli
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01 Apr 2004, 09:00
This is disheartening. I must look at E over again.
Since taking E+P does NOT increase the risk of getting cancer, then taking E+P is same as not taking it. I revert to E
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01 Apr 2004, 09:05
in C, let's say
50% of people taking nothing have U cancer
30% of people taking E alone have U cancer
We know that taking P+E will not increase risk of having cancer
Therefore, if people taking nothing start taking P+E, the number of them can still be greater than that of those taking E alone. C is refuted
Anandnk, you have too much an influence on my answers and make me think over again
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01 Apr 2004, 09:33
Nice question!

I would go with E
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01 Apr 2004, 09:51
With E unless I am missing something...
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01 Apr 2004, 16:46
I'd choose E too. This one was tough...
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02 Apr 2004, 01:00
Oh Yeah is E.
Choice E is correct. choice A compares the rates of uterine and
breast cancer which would result from taking the estrogen alone, but
the statements do not provide a basis for such a comparison. Choice B
is not specific enough. It could be true if the final phrase
read "than women taking estrogen alone", or false if the final phrase
read " than women taking estrogen and progestin". As it stands ,
choice B is indeterminate. The conditions outline in choice C would
result in the same risk for both, as is explained in the final
phrase: " however ,this combination does cause the same increase in
the risk for breast cancer as estrogen alone". Choice D mentions a
category , women taking only progestin, which is not mentioned in the
statements. If estrogen and progestin combined result in no increase
in the risk of uterine cancer, then we would expect the conditions of
the correct choice, E : women taking neither harmone and women taking
both harmones will develop uterine cancer at the same rate.
02 Apr 2004, 01:00
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# Estrogen alone increases the risk of uterine cancer and of

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