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Re: It was once believed that the brain was independent of meta [#permalink]
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P1 - a believed theory provved wrong.
P2 - proof of theory in P1.
P3 - more evidence but in reverse direction.
Main point - a theory was discarded, multiple evidences are given to prove that.

Which of the following titles best summarizes the contents of the passage?

(A) Neurotransmitters: Their Crucial Function in Cellular Communication - no
(B) Diet and Survival: An Old Relationship Reexamined - no
(C) The Blood Supply and the Brain: A Reciprocal Dependence - no
(D) Amino Acids and Neurotransmitters: The Connection between Serotonin Levels and Tyrosine - p3
(E) The Effects of Food Intake on the Production and Release of Serotonin: Some Recent Findings - to the point

--------------------------------------------
According to the passage, the speed with which tryptophan is provided to the brain cells of a rat varies with the

when we added a large amount of protein to the meal, brain tryptophan and serotonin levels fell.

(A) amount of protein present in a meal
--------------------------------------------

According to the passage, when the authors began their first studies, they were aware that

Our first studies sought to determine whether (10) the increase in serotonin observed in rats given a large injection of the amino acid tryptophan might also occur after rats ate meals that change tryptophan levels in the blood.

(E) serotonin levels increased after rats were injected with a large amount of tryptophan

---------------------------------------------

According to the passage, one reason that the authors gave rats carbohydrates was to
lines to read - We gave the rats a carbohydrate-containing meal that we knew would elicit insulin secretion.
(C) cause the rats to produce insulin
------------------------------------------------
According to the passage, the more protein a rat consumes, the lower will be the

the lower is the ratio of the resulting blood-tryptophan concentration to the concentration of competing amino acids, and the more slowly is tryptophan provided to the brain. (45) Thus the more protein in a meal, the less serotonin subsequently produced and released.

(B) ratioof the rat's blood-tryptophan concentration to the concentration in its blood of the other amino acids contained in the protein

-------------------------------------------------
The authors' discussion of the "mechanism that provides blood tryptophan to the brain cells" (lines 34-35) is meant to

PT - no doubt this is explanation for the previous findings.
(C) help explain why a particular research finding was obtained -

-------------------------------------------------

According to the passage, an injection of insulin was most similar in its effect on rats to an injection of
injecting insulin into a rat's bloodstream also caused parallel elevations in blood and brain tryptophan levels

(D) tryptophan -
-------------------------------------------

It can be inferred from the passage that which of the following would be LEAST likely to be a potential source of aid to a patient who was not adequately producing and releasing serotonin?

when we added a large amount of protein to the meal, brain tryptophan and serotonin levels fell.

(A) Meals consisting almost exclusively of protein - straight A

---------------------------------------------

Itcan be inferred from the passage that the authors initially held which of the following hypotheses about what would happen when they fed large amounts of protein to rats?

Thus the more protein in a meal, the less serotonin subsequently produced and released.

(A) The rats' brain serotonin levels would not decrease.
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1. Which of the following titles best summarizes the contents of the passage?

(A) Neurotransmitters: Their Crucial Function in Cellular Communication
This option talks about neurotransmitters in general but in the passage we are talking about a specific kind of neurotransmitter- Serotonin.

(B) Diet and Survival: An Old Relationship Reexamined. Completely out of scope.
No where in the passage survival is talked about

(C) The Blood Supply and the Brain: A Reciprocal Dependence.
This passage is about the release of serotonin and tryptophan in brain with respect to various types of food. Hence this option is out of scope.

(D) Amino Acids and Neurotransmitters: The Connection between Serotonin Levels and Tyrosine
The Connection between Serotonin Levels and Tyrosine is used as a case in point for the main point of the passage.

(E) The Effects of Food Intake on the Production and Release of Serotonin: Some Recent Findings
Exactly the gist of the passage.

2. According to the passage, the speed with which tryptophan is provided to the brain cells of a rat varies with the

(A) amount of protein present in a meal
Quote:
The more protein is in a meal, the lower is the ratio of the resulting blood-tryptophanconcentration to the concentration of competing amino acids, and the more slowly is tryptophan provided to the brain.

The above line talks about speed in the context of protein meal. Hence A is the answer.

(B) concentration of serotonin in the brain before a meal
The author says that the concentration of serotonin increases after a carbohydrate meal but nothing about its concentration before a mean and its speed.

(C) concentration of leucine in the blood rather than with the concentration of tyrosine in the blood after a meal
The author mentions leucine and tyrosine as examples of a mechansim he was explaining. Tyrosine and leucine concentration have nothing to do with the speed with which tryptophan is provided to the brain cells of a rat.
Quote:
This same mechanism also provides the brain cells with other amino acids found in protein, such as tyrosine and leucine.


(D) concentration of tryptophan in the brain before a meal
Again concentration of tryptohan in the brain before a meal was never implied in the passage.

(E) number of serotonin-containing neurons
This number is never mentioned in the passage let alone in the context of speed with which tryptophan is provided to the brain cells of a rat.

3. According to the passage, when the authors began their first studies, they were aware that

Our first studies sought to determine whether the increase in serotonin observed in rats given a large injection of the amino acid tryptophan might also occur after rats ate meals that change tryptophan levels in the blood.
Since authors already know that with the injection of tryptophan, serotonin increases, they are hoping to finding out if the same happens in the case of food.

(A) they would eventually need to design experiments that involved feeding rats high concentrations of protein
Nothing about protein is mentioned in this part of the passage.

(B) tryptophan levels in the blood were difficult to monitor with accuracy
Nothing about difficulty of monitoring.

(C) serotonin levels increased after rats were fed meals rich in tryptophan.
Our first studies sought to determine whether the increase in serotonin observed in rats given a large injection of the amino acid tryptophan might also occur after rats ate meals that change tryptophan levels in the blood.
They don't already know it.They are hoping to finding out if serotonin levels increased after rats were fed meals rich in tryptophan.


(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body.
Completely out of context.

(E) serotonin levels increased after rats were injected with a large amount of tryptophan
Correct. According to the above quoted text from the passage, we can infer this.

6. The authors' discussion of the "mechanism that provides blood tryptophan to the brain cells" (lines 34-35) is meant to

Quote:
Since protein contains tryptophan, why should it depress brain tryptophan levels? The answer lies in the mechanism that provides blood tryptophan to the brain cells. This same mechanism also provides the brain cells with other amino acids found in protein, such as tyrosine and leucine.


The author says since protein contains tryptophan and when one consumes protein, the tryptophan levels should increase in the brain. But that is not the case and he questions why. In the next line, he answers his question and says that 'due to the mechanism', this happens. So, he is mentioning 'mechanism' to explain why tryptophan levels are decreasing.

(A) stimulate further research studies
Nothing about further research was mentioned in the passage.

(B) summarize an area of scientific investigation.
Authors are not summarizing.

(C) help explain why a particular research finding was obtained
Yes. correct answer.

(D) provide supporting evidence for a controversial scientific theory
Nothing controversial was mentioned in the passage.

(E) refute the conclusions of a previously mentioned research study
The authors by saying that tryptophan levels decrease in the brain when protein rich meal is consumed, are not refuting the fact that tryptophan levels increase in the brain when meals elicit insulin secretion (mentioned in the previous passage). He is merely explaining the effect of protein on tryptophan production in brain.

8. It can be inferred from the passage that which of the following would be LEAST likely to be a potential source of aid to a patient who was not adequately producing and releasing serotonin?

(A) Meals consisting almost exclusively of protein
Quote:
Surprisingly, however, when we added a large amount of protein to the meal, brain tryptophan and serotonin levels fell.

Hence the right answer.

(B) Meals consisting almost exclusively of carbohydrates
This is likely suitable. Hence , not the answer.

(C) Meals that would elicit insulin secretion
This is most likely suitable. Hence , not the answer.

(D) Meals that had very low concentrations of tyrosine
Out of scope. We do not know the effects of tyrosine in production and release of sorotonin.

(E) Meals that had very low concentrations of leucine
Out of scope. We do not know the effects of leucine in production and release of sorotonin.
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Re: It was once believed that the brain was independent of meta [#permalink]
please provide the difficulty level and source of this passage
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Re: It was once believed that the brain was independent of meta [#permalink]
Expert Reply
hsin281 wrote:
please provide the difficulty level and source of this passage


See the screen shot

Attachment:
233.jpg
233.jpg [ 277.45 KiB | Viewed 32184 times ]


Thank you
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Re: It was once believed that the brain was independent of meta [#permalink]
Hi GMATNinja CrackVerbalGMAT MartyTargetTestPrep mikemcgarry ExpertsGlobal5 GMATGuruNY

Could you please give your suggestion why the answer can not be D . I can understand why is it C.
Quote:
Question 3 According to the passage, when the authors began their first studies, they were aware that

(A) they would eventually need to design experiments that involved feeding rats high concentrations of protein
(B) tryptophan levels in the blood were difficult to monitor with accuracy
(C) serotonin levels increased after rats were fed meals rich in tryptophan
(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body
(E) serotonin levels increased after rats were injected with a large amount oftryptophan


My reasoning:
In recent studies, however, we have discovered that the production and release (5) in brain neurons of the neurotransmitter serotonin (neurotransmitters are compounds that neurons use to transmit signals to other cells) depend directly on the food that the body processes.

Thanks in advance!!

Were the recent studies performed after first experiment. I believe recent studies should exist first and then experiment happen to confirm what is said in studies.
With this thought I think answer could also be D.

Please give your opinion.
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Re: It was once believed that the brain was independent of meta [#permalink]
mSKR wrote:
Hi GMATNinja CrackVerbalGMAT MartyTargetTestPrep mikemcgarry ExpertsGlobal5 GMATGuruNY

Could you please give your suggestion why the answer can not be D . I can understand why is it C.
Quote:
Question 3 According to the passage, when the authors began their first studies, they were aware that

(A) they would eventually need to design experiments that involved feeding rats high concentrations of protein
(B) tryptophan levels in the blood were difficult to monitor with accuracy
(C) serotonin levels increased after rats were fed meals rich in tryptophan
(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body
(E) serotonin levels increased after rats were injected with a large amount oftryptophan


My reasoning:
In recent studies, however, we have discovered that the production and release (5) in brain neurons of the neurotransmitter serotonin (neurotransmitters are compounds that neurons use to transmit signals to other cells) depend directly on the food that the body processes.

Thanks in advance!!

Were the recent studies performed after first experiment. I believe recent studies should exist first and then experiment happen to confirm what is said in studies.
With this thought I think answer could also be D.

Please give your opinion.


Hi msK, personally this is the only question that I made wrong, choosing C, but in my opinion there's no doubt that you should decide between C and E.
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Re: It was once believed that the brain was independent of meta [#permalink]
I find this passage as one of the most challenging RC passage.

One has to read this passage very carefully and invest more time on understanding the flow and context of the passage rather than understanding the contents, since the questions are based on author's point of view, why the experiments were done, whether the result were positive / negative, etc.,

This is real OLD IS GOLD type passage.
I made a lot of mistakes when I did this passage the 1st time but now after changing the way to approach a RC passage, I made 1 mistake (silly one). ;) :D :D
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Re: It was once believed that the brain was independent of meta [#permalink]
(C) serotonin levels increased after rats were fed meals rich in tryptophan
(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body
(E) serotonin levels increased after rats were injected with a large amount of tryptophan

Can you explain why ans choice C and D are wrong? GMATNinja VeritasKarishma
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Re: It was once believed that the brain was independent of meta [#permalink]
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Question 3


nikitamaheshwari wrote:
(C) serotonin levels increased after rats were fed meals rich in tryptophan
(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body
(E) serotonin levels increased after rats were injected with a large amount of tryptophan

Can you explain why ans choice C and D are wrong? GMATNinja VeritasKarishma

Let's consider the following key points from the passage:

  • It was "once believed that the brain was independent of metabolic processes occurring elsewhere in the body."
  • The authors of the passage recently performed studies showing this was not the case (i.e. some neurotransmitters are dependent on food processed by the body).
  • The authors recently conducted a study to see how eating affected tryptophan levels in rats.
  • This study was based on the previous observation that rats given "a large injection of the amino acid tryptophan" experienced an increase in serotonin.

Now let's consider (C):
Quote:
(C) serotonin levels increased after rats were fed meals rich in tryptophan

This is exactly what the authors found in their first study. But the question asks what the authors were aware of WHEN they began their first studies. In other words -- the right answer should be something the authors were already aware of BEFORE their first study. Since the authors weren't aware of this until AFTER they performed their study, (C) is wrong.

Let's consider (D):
Quote:
(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body

Again, this is something the authors found during their study. Since they weren't aware of this fact BEFORE their study, (D) is out.

Now take a look at (E):
Quote:
(E) serotonin levels increased after rats were injected with a large amount of tryptophan

According to the passage, the authors were aware that "a large injection of the amino acid tryptophan" caused serotonin levels to increase in rats. Based on this fact, their study sought to confirm whether eating would also cause serotonin to increase in rats.

Since they were aware of this fact BEFORE their study, (E) is correct.

I hope that helps!
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Re: It was once believed that the brain was independent of meta [#permalink]
GMATNinja MartyTargetTestPrep KarishmaB

Hi Experts,
6. The authors' discussion of the "mechanism that provides blood tryptophan to the brain cells" (lines 34-35) is meant to -
(C) help explain why a particular research finding was obtained
(D) provide supporting evidence for a controversial scientific theory

Why D is incorrect?
The scientific theory is that large amount of protein will also increase serotonin level but the result was different. To support this controversial finding, the lines 34-35 provide supporting evidence by introducing "mechanism" that helps to explain this finding.

Why C is correct?
C says mechanism helps explain why we did protein experiment. I believe the mechanism helps to explain the result of the protein experiment.

Please help to understand how C is correct.

Thanks for your time!
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It was once believed that the brain was independent of meta [#permalink]
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carcass wrote:
It was once believed that the brain was
independent of metabolic processes occurring
elsewhere in the body. In recent studies, however,
we have discovered that the production and release
(5) in brain neurons of the neurotransmitter serotonin
(neurotransmitters are compounds that neurons use
to transmit signals to other cells) depend directly on
the food that the body processes.

Our first studies sought to determine whether
(10) the increase in serotonin observed in rats given
a large injection of the amino acid tryptophan
might also occur after rats ate meals that change
tryptophan levels in the blood. We found that,
immediately after the rats began to eat, parallel
(15) elevations occurred in blood tryptophan, brain
tryptophan, and brain serotonin levels. These
findings suggested that the production and release
of serotonin in brain neurons were normally coupled
with biood-tryptophan increases. In later studies we
(20) found that injecting insulin into a rat's bloodstream
also caused parallel elevations in blood and brain
tryptophan levels and in serotonin levels. We then
decided to see whether the secretion of the animal's
own insulin similarly affected serotonin production.
(25) We gave the rats a carbohydrate-containing meal
that we knew would elicit insulin secretion. As we
had hypothesized, the blood tryptophan level and
the concentrations of tryptophan and of serotonin
in the brain increased after the meal.

(30) Surprisingly, however, when we added a large
amount of protein to the meal, brain tryptophan
and serotonin levels fell. Since protein contains
tryptophan, whyshould it depress brain tryptophan
levels? The answer lies in the mechanism that
(35) provides blood tryptophan to the brain cells. This
same mechanism also provides the brain cells with
other amino acids found in protein, such as tyrosine
and leucine. The consumption of protein increases
blood concentration of the other amino acids much
(40) more, proportionately, than it does that of tryptophan.
The more protein is in a meal, the lower is the ratio
of the resulting blood-tryptophanconcentration to
the concentration of competing amino acids, and
the more slowly is tryptophan provided to the brain.
(45) Thus the more protein in a meal, the less serotonin
subsequently produced and released.


1.Which of the following titles best summarizes the contents of the passage?

(A) Neurotransmitters: Their Crucial Function in Cellular Communication
(B) Diet and Survival: An Old Relationship Reexamined
(C) The Blood Supply and the Brain: A Reciprocal Dependence
(D) Amino Acids and Neurotransmitters: The Connection between Serotonin Levels and Tyrosine
(E) The Effects of Food Intake on the Production and Release of Serotonin: Some Recent Findings



2. According to the passage, the speed with which tryptophan is provided to the brain cells of a rat varies with the

(A) amount of protein present in a meal
(B) concentration of serotonin in the brain before a meal
(C) concentration of leucine in the blood rather than with the concentration of tyrosine in the blood after a meal
(D) concentration of tryptophan in the brain before a meal
(E) number of serotonin-containing neurons



3. According to the passage, when the authors began their first studies, they were aware that

(A) they would eventually need to design experiments that involved feeding rats high concentrations of protein
(B) tryptophan levels in the blood were difficult to monitor with accuracy
(C) serotonin levels increased after rats were fed meals rich in tryptophan
(D) there were many neurotransmitters whose production was dependent on metabolic processes elsewhere in the body
(E) serotonin levels increased after rats were injected with a large amount of tryptophan



4. According to the passage, one reason that the authors gave rats carbohydrates was to

(A) depress the rats' tryptophan levels
(B) prevent the rats from contracting diseases
(C) cause the rats to produce insulin
(D) demonstrate that insulin is the most important substance secreted by the body
(E) compare the effect of carbohydrates with the effect of proteins



5. According to the passage, the more protein a rat consumes, the lower will be the

(A) ratio of the rat's blood-tryptophan concentration to the amount of serotonin produced and released in the rat's brain
(B) ratio of the rat's blood-tryptophan concentration to the concentration in its blood of the other amino acids contained in the protein
(C) ratio of the rat's blood-tyrosine concentration to its blood-leucine concentration
(D) number of neurotransmitters of any kind that the rat will produce and release
(E) number of amino acids the rat's blood will contain




6. The authors' discussion of the "mechanism that provides blood tryptophan to the brain cells" (lines 34-35) is meant to

(A) stimulate further research studies
(B) summarize an area of scientific investigation
(C) help explain why a particular research finding was obtained
(D) provide supporting evidence for a controversial scientific theory
(E) refute the conclusions of a previously mentioned research study



7. According to the passage, an injection of insulin was most similar in its effect on rats to an injection of

(A) tyrosine
(B) leucine
(C) blood
(D) tryptophan
(E) protein



8. It can be inferred from the passage that which of the following would be LEAST likely to be a potential source of aid to a patient who was not adequately producing and releasing serotonin?

(A) Meals consisting almost exclusively of protein
(B) Meals consisting almost exclusively of carbohydrates
(C) Meals that would elicit insulin secretion
(D) Meals that had very low concentrations of tyrosine
(E) Meals that had very low concentrations of leucine



9. It can be inferred from the passage that the authors initially held which of the following hypotheses about what would happen when they fed large amounts of protein to rats?

(A) The rats' brain serotonin levels would not decrease.
(B) The rats' brain tryptophan levels would decrease.
(C) The rats' tyrosine levels would increase less quickly than would their leucine levels.
(D) The rats would produce more insulin.
(E) The rats would produce neurotransmitters other than serotonin.



Try this under time condition. Good luck
As usual are glad answers and explanations
Regards


Sneha2021

Note how the previous paragraph ends and the new paragraph begins.

As we had hypothesized, the blood tryptophan level and the concentrations of tryptophan and of serotonin in the brain increased after the meal.

Surprisingly, however, when we added a large amount of protein to the meal, brain tryptophan and serotonin levels fell.
The answer lies in the mechanism that provides blood tryptophan to the brain cells. This same mechanism also provides the brain cells with other amino acids found in protein, such as tyrosine and leucine...


The previous paragraph talks about expected results obtained in the study. This paragraph starts with how an unexpected result was obtained (highlighted). The next line explains why this result was obtained - why a large amount of protein in the meal made brain tryptophan and serotonin levels fall. It tells us that the same mechanism provides other amino acids too and tryptophan loses is the competition.

6. The authors' discussion of the "mechanism that provides blood tryptophan to the brain cells" (lines 34-35) is meant to[/b]

(A) stimulate further research studies
(B) summarize an area of scientific investigation
(C) help explain why a particular research finding was obtained
(D) provide supporting evidence for a controversial scientific theory
(E) refute the conclusions of a previously mentioned research study

Hence, what is the purpose of this discussion? Why does he mention the mechanism? To explain why we got the surprising result. Hence (C) works. He does mention it to explain a finding.

(D) is not correct because no controversial theory has been discussed. He open the first paragraph with what was once believed (brain was
independent of metabolic processes) but now has been shown to be incorrect (brain is impacted by metabolic processes). Then he goes on to explain how the brain is impacted (the results established by studies). Then he gives a surprising impact of metabolic processes on the brain and then goes on to explain why it is so. There is no discussion on 'controversial theory'. A controversial theory would a belief held by some while others would not agree etc.
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Re: It was once believed that the brain was independent of meta [#permalink]
someone please tell what is min ideal time to solve all 9 questions
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Re: It was once believed that the brain was independent of meta [#permalink]
completed in 8 mins 48s with 9 correct
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Re: It was once believed that the brain was independent of meta [#permalink]
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