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OA should be C.

A. typically causes death within 3 to 5 years of the onset of symptoms, on average, the famous physicist Stephen Hawking has defied the odds, in contrast,

"in contrast" is not required with Although. Also, typically and average cause redundancy when used together.

B. causes death within 3 to 5 years of the onset of symptoms, on average, the famous physicist Stephen Hawking has defied the odds, in contrast,

Same as A.

C. typically causes death within 3 to 5 years of the onset of symptoms, the famous physicist Stephen Hawking has defied the odds. CORRECT
"in contrast" is omitted and "average" is also not used.

D. causes death within 3 to 5 years of the average onset of symptoms, the famous physicist Stephen Hawking has defied the odds, by contrast,

Same as A.

E. typically causes death within 3 to 5 years of the average onset of symptoms, the famous physicist Stephen Hawking has defied the odds

Same as A. Also the sentence makes no sense.

Hence option C
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Bunuel
Although amyotrophic lateral sclerosis, or ALS, typically causes death within 3 to 5 years of the onset of symptoms, on average, the famous physicist Stephen Hawking has defied the odds, in contrast, by living more than 40 years after his initial diagnosis.


A. typically causes death within 3 to 5 years of the onset of symptoms, on average, the famous physicist Stephen Hawking has defied the odds, in contrast,

B. causes death within 3 to 5 years of the onset of symptoms, on average, the famous physicist Stephen Hawking has defied the odds, in contrast,

C. typically causes death within 3 to 5 years of the onset of symptoms, the famous physicist Stephen Hawking has defied the odds

D. causes death within 3 to 5 years of the average onset of symptoms, the famous physicist Stephen Hawking has defied the odds, by contrast,

E. typically causes death within 3 to 5 years of the average onset of symptoms, the famous physicist Stephen Hawking has defied the odds

+1 for C !!
Use of "in contrast" in A and B and "by contrast" in D is wrong.
Also E uses average in the wrong place.
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defied the odds + in/by contrast - redundant - Eliminate A, B & D

E - of the average onset of symptoms - illogical - OUT

C is the answer
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