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People with higher-than-average blood levels of a normal dietary by-product called homocysteine are twice as likely to be diagnosed with Alzheimer's disease as are those with average or below-average homocysteine levels. Thus, it is likely that the risk of developing Alzheimer's disease could be reduced by including in one's diet large amounts of B vitamins and folic acid, which convert homocysteine into substances known to have no relation to Alzheimer's disease.

Which one of the following, if true, most seriously weakens the argument?

(A) Many Alzheimer's patients have normal homocysteine levels.
Fact Statement. Twice as likely doesn't mean that Alzheimer's patients can't have normal level of homocysteine levels

(B) The substances into which homocysteine is converted can sometimes have harmful effects unrelated to Alzheimer's disease.
Not worried about other harmful effects

(C) B vitamins and folic acid are not metabolized by the body very efficiently when taken in the form of vitamin-mineral supplements.
Okay, then give the vitamin and acid in some other form. Irrelevant

(D) People whose relatives contracted Alzheimer's disease are much more likely to develop Alzheimer's than those whose relatives did not.
Okay, let it be the case. Still the patients will have high homocysteine levels

(E) Alzheimer's disease tends to increase the levels of homocysteine in the blood.
Correct. It reverses the causallity. Alzheimer's disease causes high levels of homocysteine
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Argument says :

higher level of homocysteine ->high blood level -> disease

weaken will say disease leads to high level of H
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