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(1) 42 people -> 42C2 = 861 handshakes --- But this includes handshakes among family members.
(2) 2C2 = 1 handshake --- the handshake between Chris and his wife.
(3) 4C2 x 10 = 60 handshakes --- each family invited by Chris has 4 members. There would be 4C2 handshakes within this family. There are 10 such families. So, a total of 4C2 x 10 = 60 handshakes

Our answer: (1) - (2) - (3) = 861 - 1 - 60 = 800 handshakes.

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