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This question is not well designed. For either statement to talk about multiples in the first place, the stem needs to tell us that p and q are integers. *Real* GMAT questions about multiples and divisibility always only deal with *positive* integers. Because of that, I think it's reasonable to assume p and q are positive integers here and that the question designer was just too careless to mention that fact. If that's the case, then if p is a multiple of q and q is a multiple of p, it must be that p=q, and the information is sufficient, so the answer is C.
If, on the other hand, p or q could be negative, then the answer is E, but that's testing a technicality that is always irrelevant on real GMAT multiples questions.
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