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Clear E. advances is plural should use "mark"
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cultural and academic advances --> marked the end of the period known as Dark Ages

In the late fifteenth century, according to many historians, the growth of an increasingly powerful mercantile class led to the emergence of economic nationalism in Europe, which, causing cultural and academic advances, mark the end of the period known as the Dark Ages.

* which, causing cultural and academic advances, mark
* causing cultural and academic advances, it marks
* and causing cultural and academic advances that mark
* an ideology that caused the cultural and academic advances, and it had marked
* an ideology that caused the cultural and academic advances that mark - CORRECT



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