Yes, if x + 4 were a factor of some quadratic, then plugging x = -4 into that quadratic will give you a result of zero. So for example, x + 4 is a factor of this quadratic:
x^2 + 7x + 12 = (x + 4)(x + 3)
and if you plug x = -4 into this quadratic, the result will be zero.
But notice also: if x is a positive integer, then x^2 + 7x + 12 will
always be divisible by x+4, because you can write the number x^2 + 7x + 12 as a product of two smaller integers, using the factorization above. In the question Bunuel posted above, n+4 is definitely
not a factor of the quadratic n^2 + 6n + 16, because n^2 + 6n + 16 is not divisible by n+4 for every single value of n. It's only divisible by n+4 for certain values of n.
If that's confusing at all, it might help to think of much simpler situations: Say k is a positive integer:
* Algebraically speaking, k is a factor of 2k. So 2k is
always divisible by k, no matter what k equals
* Algebraically speaking, k is not a factor of k + 2. But k could still sometimes be a divisor of k+2 for certain values of k. It turns out here that it is, only when k = 1 and k = 2.