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Bunuel
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A. Smoking is unhealthy to such a large degree that it could significantly shorten one's life
Unnecessarily wordy option -> to such a large degree

B. Smoking is so unhealthy that it could significantly shorten one's life
Looks Good -> so...that...is correctly used

C. Smoking is unhealthy to a large enough degree as to significantly shorten one's life
Unnecessarily wordy option -> to a large enough degree

D. So not healthy is smoking that it could shorten one's life to a significant extent
Improper construction

E. Smoking is so unhealthy that it could shorten one's life
the choice misses an important word - significant else it is the same as option B
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