Though looking less distinctive than many of their highly sought-after purebred counterparts, mixed-breed dogs, born from genetically disparate parents—they usually display various physical characteristics from each parent—often they are healthier and thus increasingly popular.
1. This topic exploits the wrong structural construction of sentences.
2. Unnecessary off intrusion off pronouns will lead to double subjecting errors.A. Though looking less distinctive than many of their highly sought-after purebred counterparts, mixed-breed dogs, born from genetically disparate parents --- lacks a verb for the main clause. A fragment by structure,
B. Though mixed-breed dogs, born from genetically disparate parents, look less distinctive than their highly sought-after purebred counterparts --
-Looks okay, This is the correct choice C. Though they look less distinctive than many of their highly sought-after purebred counterparts, mixed-breed dogs, born from genetically disparate parents --- lacks a verb for the main clause.
D. Born from genetically disparate parents, mixed-breed dogs look less distinctive than many of their highly sought-after purebred counterparts—this is a run-on sentence
E. Mixed-breed dogs, born from genetically disparate parents, though they look less distinctive than many of their highly sought-after purebred counterparts --- no verb for the main part.