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A) Whether the creams affect all areas that they are applied to equally
Incorrect. The dispute is about safety, not evenness of skin lightening.

B) Whether treatments for hyperpigmentation disorders use metal compounds to reduce melanin production
Incorrect. Even if some medical treatments use similar compounds, that does not prove these creams are safe.

C) Whether the typical amount described by the defender is the amount absorbed via one use or a cumulative amount, absorbed over a lifetime

Correct.
A small one-time dose may be harmless, but repeated use over months or years could create harmful cumulative exposure.

D) The cultural impact of skin-whitening creams
Incorrect. Cultural effects do not help determine whether the compounds create health problems.

E) Whether the skin-whitening creams were tested for safety on a broad cross-section of the population
Incorrect, It does not directly resolve the defender’s specific claim comparing absorbed dose to gasoline smoke exposure.

ExpertsGlobal5
Many skin-whitening creams and similar cosmetics utilize heavy metal compounds to block the production of the skin pigment melanin. The metal compounds bleach the skin by destroying melanocytes, the cells that produce melanin, lightening the skin’s tone. Critics fear that exposure to these compounds could have numerous negative health effects, including a heightened risk of skin cancer, but a defender responds, “The average dose of metal compounds absorbed via skin-whitening creams is less than what one might absorb from a few minutes of exposure to gasoline smoke. Using these creams will not hurt anyone.”

Which of the following issues would it be most important to resolve in evaluating the dispute concerning the health effects of the skin-whitening creams?

A. Whether the creams affect all areas that they are applied to equally
B. Whether treatments for hyperpigmentation disorders use metal compounds to reduce melanin production
C. Whether the typical amount described by the defender is the amount absorbed via one use or a cumulative amount, absorbed over a lifetime
D. The cultural impact of skin-whitening creams
E. Whether the skin-whitening creams were tested for safety on a broad cross-section of the population



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