The argument presented in the passage is that cannabinoids probably function to stimulate the appetite. This conclusion is based on the observation that when newborn mice were injected with a chemical that blocks cannabinoids from reaching their receptors in the brain, they showed far less interest in feeding than normal newborn mice do.
Option E states that "The chemical that blocks cannabinoids from stimulating their brain receptors does not independently inhibit the appetite." This is an assumption on which the argument depends because if the chemical used to block cannabinoids independently inhibited the appetite, then the observed decrease in feeding behavior could be due to the chemical itself rather than the blocking of cannabinoids. In other words, if option E were not true, then the conclusion that cannabinoids probably function to stimulate the appetite would be weakened.
Option A states that "Newborn mice do not normally ingest any substance other than their mothers' milk." This is not an assumption on which the argument depends because even if newborn mice ingested other substances, it would not affect the conclusion that cannabinoids probably function to stimulate the appetite.
Option B states that "Cannabinoids are the only substances in mammals' milk that stimulate the appetite." This is not an assumption on which the argument depends because even if there were other substances in mammals' milk that stimulated the appetite, it would not affect the conclusion that cannabinoids probably function to stimulate the appetite.
Option C states that "The mothers of newborn mice do not normally make any effort to encourage their babies to feed." This is not an assumption on which the argument depends because even if mothers of newborn mice made efforts to encourage their babies to feed, it would not affect the conclusion that cannabinoids probably function to stimulate the appetite.
Option D states that "The milk of mammals would be less nutritious if it did not contain cannabinoids." This is not an assumption on which the argument depends because even if milk were less nutritious without cannabinoids, it would not affect the conclusion that cannabinoids probably function to stimulate the appetite.