Do you mean "premise" by "issue" and "conclusion" by "argument" ? If so, yes, they could appear in even more complicated ways as Premise-Conclusion-Premise. There are even arguments (the combination of premises and a conclusion) with more than one conclusions.
I would say that finding the conclusion is not the most difficult part in CR quesions, but the establishment of strong assumption (the hidden premise). Read some basic materials concerning CR questions