A study of the benefits of a family of cholesterol-lowering drugs used in the treatment of heart attacks has shown that while the greatest benefits are enjoyed by those at greatest risk of a vascular event, every person at risk can gain considerable benefits from the treatment.These findings have led to calls that it should be offered to anybody at risk of a heart attack or stroke. It has long been known that the treatment, if administered daily to the group most at risk of an attack, cuts that risk by a third. At present, doctors prescribe the treatment only once they have considered a number of factors, including cholesterol level, blood pressure, body fat levels and whether the patient smokes. The new evidence suggests that patients with less than very high levels of cholesterol will also experience a significant drop in their cholesterol levels and a consequent lower risk of a vascular event. In fact, it concludes that the benefits of the treatment are directly proportional to the size of the reduction in cholesterol levels that might be achieved and not the level at which the intervention begins.
1. Which of the following is a factor that gave rise to the call that the treatment should be offered to anybody at risk of a heart attack or stroke?A. the realization that the treatment is literally a life saver
B. the realization that not every person at risk can gain considerable benefits from the treatment
C. the realization that in those most at risk the treatment reduces the risk of an attack by as much as a third
D. the realization that the risk of a heart attack is much higher in people who smoke, are overweight and have high cholesterol levels and blood pressure
E. the realization that benefits from the treatment were seen in many different patient types
2. The treatment is:A. a single drug
B. a family of related drugs
C. an unspecified intervention
D. a series of painful injections
E. administered daily
3. The best summary of the conclusion to be drawn from the evidence of the study is that:A. The benefits of the treatment are directly proportional to the size of the reduction in cholesterol levels that might be achieved and not the level at which intervention begins.
B. This treatment could cut heart attacks by a third.
C. The treatment should be prescribed to anyone assessed to be at risk of a heart attack or stroke.
D. There is now a much stronger case for the treatment to be prescribed to a much wider group of patients.
E. The greatest benefits are enjoyed by those at greatest risk of a vascular event.
4. Given that the benefits of the treatment are directly proportional to the size of the reduction in cholesterol levels it is correct to say that:A. Doctors should offer this treatment to everybody they believe are at risk of a heart attack regardless of their cholesterol levels.
B. Taking the treatment on a daily basis can cut the risk of a heart attack and stroke by a third.
C. The treatment may not benefit as wide a range of patients as was originally thought.
D. Everyone could gain considerable benefits from the treatment.
E. Doctors should look more to the relative drop in cholesterol that may be achieved, rather than prioritizing patients suffering the very highest levels.
5. Which of the statements, if true, would most weaken the claim that patients with less than very high levels of cholesterol will also experience a significant drop in their cholesterol levels and consequently a much lower risk of a vascular event?A. The largest benefits from the treatment are seen among those in greatest risk of a vascular event, and those with less than very high levels of cholesterol are not at greatest risk.
B. Unfortunately, the best results from the treatment are only obtained when the treatment is customized to the individual patient’s cholesterol levels and requires someone with less than very high cholesterol levels to take a smaller daily dose.
C. Preliminary evidence suggests that the treatment achieves a relatively small reduction in the risk of a heart attack among people with less than very high levels of cholesterol.
D. Not all the evidence is positive, as people with lower cholesterol levels who take the treatment have been found to develop an increased risk of some cancers.
E. Originally, it was thought that the treatment worked by lowering the cholesterol level, but it is now believed that this effect alone is not enough to account for all the advantages that the treatment provides.