The passage is saying multiple things that were against Al smith but not a single thing in his support, and the question is asking for inference supported by the statement. so the inference should be something that must be true based on above statement.
A: yes, according to passage it can be true.. lets keep this option for safe side
B: if we see, He was from New York City, viewed even in the early 20th century as disconnected from the national character. ok this shows newyork is a city but still we cant be sure where most of the american lived so not correct.
C:Not stated anywhere
D:passage is only showing his weaknesses none of his works if he did any to overcome it.
E: its mentioned that he lost backing of many party leader because he favored repeal of prohibition, but Prohibition had been put into place through the work of party leader is not mentioned.
hence
Option A looks like correct answer PS: not sure if i am correct