Clause acting as a Subject of another clause must be a Dept. Clause

Question

I found this interesting Example:
1. That fever drives the migration of heat-shock proteins toward the sites of infection has been known for a while.
2. fever drives the migration of heat-shock proteins toward the sites of infection has been known for a while.

Many people might say that sentence number 2 is correct.
But in fact, 1 is the correct sentence.

See, for a clause to act a subject of another clause, that clause needs to be a Dependent Clause.
In Sent. 1, "that" does the work of making "fever drives ..... infection" a dependent clause.

While in 2, the absence of "that" makes the "fever drives ..... infection" a Independent Clause, therefore the verb "is" doesn't have any proper subject in 2.

chetan2u · Answer

Yes, you are right. 
2 is not correct because it has two verbs. 
fever  drives  the migration of heat-shock proteins toward the sites of infection  has  been known for a while.

On the other hand verb ‘drives’ becomes a part of noun clause acting as the subject by placing of THAT. The verb is always SINGULAR in these cases.

Clause acting as a Subject of another clause must be a Dept. Clause

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