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26 Apr 2020, 09:39
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In a finding that may challenge popular notions of body fat and health, researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown how fat cells can protect the body against diabetes. The results may lead to a new therapuetic strategy for preventing and treating type 2 diabetes and obesity-related metabolic diseases, the author says. In the study, the BIDMC researchers pinpointed the fat gene and its effect in mouse models of human obesity and insulin resistance and reported supporting evidence from fat tissue samples from both lean and obese people. "Two things were surprising -- first, that a lone gene could shift the metabolism of the fat cell so dramatically and then, that turning on this master switch selectively in adipose tissue is beneficial to the whole body," said senior author Barbara Kahn MD, the George R. Minot Professor of Medicine at Harvard Medical School and Vice Chair of the Department of Medicine at BIDMC. Twelve years ago, Kahn first demonstrated that fat cells are a master regulator of healthy levels of glucose and insulin in mice and require sugar to do the job.
Type 2 diabetes mellitus is now recognized as a metabolic syndrome and although the treatment paradigm has shifted from one that focuses solely on glycemic control to one addressing global cardiovascular risk factors in a particular individual, glycemic control remains one of the key challenges that the physician faces in his daily practice. The practicing physician must be familiar with the basic pharmacology of the various classes of hypoglycemic drugs to ensure its effective and rational use. This is becoming an increasingly complicated task given the rapid pace of progress in diabetes therapy. There is also a need to appreciate the pathophysiology of type 2 diabetes and the concept of insulin resistance and b-cell dysfunction, and how this may influence the choice of therapeutic agents in any particular patient.
Type 2 diabetes mellitus is now recognized as a metabolic syndrome and although the treatment paradigm has shifted from one that focuses solely on glycemic control to one addressing global cardiovascular risk factors in a particular individual, glycemic control remains one of the key challenges that the physician faces in his daily practice. The practicing physician must be familiar with the basic pharmacology of the various classes of hypoglycemic drugs to ensure its effective and rational use. This is becoming an increasingly complicated task given the rapid pace of progress in diabetes therapy. There is also a need to appreciate the pathophysiology of type 2 diabetes and the concept of insulin resistance and b-cell dysfunction, and how this may influence the choice of therapeutic agents in any particular patient.
The number of physicians who can satisfactorily treat diabetes is decreasing as new classes of hypoglycemic drugs create rapid changes in therapeutic diabetes treatment.: No
Dr. Khan does not support oral hypoglycemic drugs.: No
A family genetically pre-disposed to diabetes should avoid traveling in countries like India and Malaysia, in order to protect themselves from diabetes exposure.: No
Be sure to select an answer first to save it in the Error Log before revealing the correct answer (OA)!
Difficulty:
65%
(hard)
Question Stats:
67% (03:37) correct
33%
(02:36)
wrong
based on 97
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Time
Result
Not Attempted Yet
1. Consider each of the following statements. Does the information in the three articles support the inference as stated?
| Yes | No | |
| The number of physicians who can satisfactorily treat diabetes is decreasing as new classes of hypoglycemic drugs create rapid changes in therapeutic diabetes treatment. | ||
| Dr. Khan does not support oral hypoglycemic drugs. | ||
| A family genetically pre-disposed to diabetes should avoid traveling in countries like India and Malaysia, in order to protect themselves from diabetes exposure. |
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Official Answer
The number of physicians who can satisfactorily treat diabetes is decreasing as new classes of hypoglycemic drugs create rapid changes in therapeutic diabetes treatment.: No
Dr. Khan does not support oral hypoglycemic drugs.: No
A family genetically pre-disposed to diabetes should avoid traveling in countries like India and Malaysia, in order to protect themselves from diabetes exposure.: No
knowledge of the various kinds of hypoglycemic drugs.
Be sure to select an answer first to save it in the Error Log before revealing the correct answer (OA)!
Difficulty:
95%
(hard)
Question Stats:
13% (01:03) correct
87%
(01:20)
wrong
based on 161
sessions
History
Date
Time
Result
Not Attempted Yet
2. All of the following are important characteristics of a physician dealing with a type 2 diabetes patient EXCEPT
| knowledge of the various kinds of hypoglycemic drugs. | |
| understanding of how type 2 diabetes can develop when insulin does not do its job of lowering blood sugar levels. | |
| understanding that a fat gene can operate as a switch for turning type 2 diabetes on and off. | |
| understanding that patients in Asia Pacific regions are more at risk for type 2 diabetes than in other parts of the world. | |
| understanding that diabetes is a metabolic disease and not a cardiovascular one. |
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Official Answer
knowledge of the various kinds of hypoglycemic drugs.
Dr. Khan does not believe there is only a singular treatment option for type 2 diabetes.: Yes
Treatment of type 2 diabetes is complex and involves many variables.: Yes
Contrary to popular belief, not all fat genes are bad for the human body.: Yes
Be sure to select an answer first to save it in the Error Log before revealing the correct answer (OA)!
Difficulty:
65%
(hard)
Question Stats:
40% (00:51) correct
60%
(01:03)
wrong
based on 108
sessions
History
Date
Time
Result
Not Attempted Yet
3. Consider each of the following statements. Does the information in the three articles support the inference as stated?
| Yes | No | |
| Dr. Khan does not believe there is only a singular treatment option for type 2 diabetes. | ||
| Treatment of type 2 diabetes is complex and involves many variables. | ||
| Contrary to popular belief, not all fat genes are bad for the human body. |
ShowHide Answer
Official Answer
Dr. Khan does not believe there is only a singular treatment option for type 2 diabetes.: Yes
Treatment of type 2 diabetes is complex and involves many variables.: Yes
Contrary to popular belief, not all fat genes are bad for the human body.: Yes
26 Apr 2020, 10:30
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1)For all of the questions the answer would be no since nothing mentioned above in related to anything present in the above articles.
2)I think the answer is A here since only the knowledge of hypoglycemic drugs is not important because other factors such as insulin resistance and b-cell dysfunction also influence the type of medication to be given.
3)Yes to all since all of them can be easily inferred from the first paragraph since Dr Kahn belive that there are multiple factors in terms of treating type 2 diabetes and it is very complex and need to look upon several dependencies and not all fat genes are bad for the body as suggested by the surprising findings of the study above
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2)I think the answer is A here since only the knowledge of hypoglycemic drugs is not important because other factors such as insulin resistance and b-cell dysfunction also influence the type of medication to be given.
3)Yes to all since all of them can be easily inferred from the first paragraph since Dr Kahn belive that there are multiple factors in terms of treating type 2 diabetes and it is very complex and need to look upon several dependencies and not all fat genes are bad for the body as suggested by the surprising findings of the study above
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bM22
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27 Apr 2020, 04:14
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Just one concern: Journal and magazine have the exactly same article added, no difference in the 2, none the less, below is my explanation for the questions.
1. No for all the options, since nothing mentioned in the options can be inferred from any of the 3 articles.
2. Although the official answer provided is A, shouldn't it be D??? since all of the other options are mentioned in the passage as important points for a physician to know when treating a diabetes 2 patient, but D : "understanding that patients in Asia Pacific regions are more at risk for type 2 diabetes than in other parts of the world.", is not that an important factor.
Also A is mentioned in the 1st article as: "The practicing physician must be familiar with the basic pharmacology of the various classes of hypoglycemic drugs to ensure its effective and rational use. ", which makes it a valid point for the physicians to have knowledge of.
D is clearly not an important characteristics of a physician dealing with a type 2 diabetes patient.
SajjadAhmad kindly correct if my understanding is wrong.
3. A simple one, all yes, since all of the points can be inferred from the 1st article alone.
1. No for all the options, since nothing mentioned in the options can be inferred from any of the 3 articles.
2. Although the official answer provided is A, shouldn't it be D??? since all of the other options are mentioned in the passage as important points for a physician to know when treating a diabetes 2 patient, but D : "understanding that patients in Asia Pacific regions are more at risk for type 2 diabetes than in other parts of the world.", is not that an important factor.
Also A is mentioned in the 1st article as: "The practicing physician must be familiar with the basic pharmacology of the various classes of hypoglycemic drugs to ensure its effective and rational use. ", which makes it a valid point for the physicians to have knowledge of.
D is clearly not an important characteristics of a physician dealing with a type 2 diabetes patient.
SajjadAhmad kindly correct if my understanding is wrong.
3. A simple one, all yes, since all of the points can be inferred from the 1st article alone.
