Understanding the argument -
Researchers have found that when very overweight people, who tend to have relatively low metabolic rates, lose weight primarily through dieting, their metabolism generally remain unchanged. Fact
They will thus burn significantly fewer calories at the new weight than do people whose weight is normally at that level. Opinion.
Such newly thin persons will, therefore, ultimately regain weight until their body size again matches their metabolic rate. - Conclusion.
The assumption is that the "newly thin persons" can't continue dieting.
Option Elimination -
(A) Relatively few very overweight people who have dieted down to a new weight tend to continue to consume substantially fewer calories than do people whose normal weight is at that level. Ok. Negated choice
The logical negation of "few," which is equivalent to some, is "No" or "none."
The logical opposite of "fewer," which indicates a smaller quantity, is "more," which means a larger or more significant quantity. So, the negated option is
None of the very overweight people who have dieted down to a new weight tend to continue to consume substantially more calories than do people whose normal weight is at that level. If no one continues more calories, then the conclusion breaks.
(B) The metabolisms of people who are usually not overweight are much more able to vary than the metabolisms of people who have been very overweight. - We don't know, and it doesn't matter. Out of scope.
(C) The amount of calories that a person usually burns in a day is determined more by the amount that is consumed that day than by the current weight of the individual. It shifts the focus, which is the effect of dieting on weight, to comparing the amount consumed and the person's weight. At best, it's contradictory. The argument says that very overweight people have a relatively low metabolic rate. So more weight - low metabolic rate - less calories burn. Distortion.
(D) Researchers have not yet determined whether the metabolic rates of formerly very overweight individuals can be accelerated by means of chemical agents. - This is a perfect trap answer. But the problem is that it shifts the focus. Our scope is limited to the effect of dieting and weight. Chemicals (further diving into the metabolic rates) are out of scope. Moreover, even if they have determined it doesn't mean they can administer the same to the very overweight people right away. We don't know. Too much to assume to make it work. Out of scope.
(E) Because of the constancy of their metabolic rates, people who are at their usual weight normally have as much difficulty gaining weight as they do losing it. Out of scope.