Originally found in parasites belonging to the order of kinetoplastids, DNA base "J", an unusual minor base
known as the only hyper-modified DNA base in eukaryotes and that resembles thymine, has been proven to control antigenic variation; exist in the DNA of euglenids, evidence for a close relation between kinetoplastids and euglenids; and cause certain severe diseases.
(A) known as the only hyper-modified DNA base in eukaryotes and that resembles
There is a pronoun ambiguity - What is that refer to? It can be DNA base "J" or eukaryotes . Logically it should refer to "eukaryotes". -
Incorrect.
(B) known as the only hyper-modified DNA base in eukaryotes and that, resembling
", resembling" makes it even more spooky. Now it is a verbing modifier and should modify the previous clause which it doesn't. -
Incorrect(C) known as the only hyper-modified DNA base in eukaryotes and resembling
Now the structure is correct.
"an unusual minor base" is an modifier which says about DNA base "J" and "and" separates the clause and subject is still "DNA base "J""
Hence the sentence becomes "DNA base "J" resembling thymine "- this is another modifier modifying the subject - DNA base "J". -
Correct.
(D) that is known as the only hyper-modified DNA base in eukaryotes and it resembles
that actually a relative pronoun and refers to "DNA base "J"" so the sentence structure is completely wrong. If we break this in clauses.
DNA base "J", an unusual minor base
that is known as as the only hyper-modified DNA base in eukaryotes and
it resembles thymine.
But there is no predicate for the subject "an unusual minor base" - it is hanging here -
Incorrect.
(E) that is known as the only hyper-modified DNA base in eukaryotes and that, resembling
Same issue as above. -
Incorrect.