Official Solution:
Scientists have found that during deep (“stage-4”) sleep the nervous system resets levels of a pain-amplifying chemical called neuropeptide substance P. If this nightly reset fails, substance P continues to sensitize nerves, eventually spreading pain throughout the body. Therefore, getting sufficient stage-4 sleep is essential to preventing fibromyalgia.
The theory above on the cause of fibromyalgia rests on which of the following assumptions?
A. Only stage-4 sleep can restore substance P to its normal, non-sensitizing level.
B. The amount of stage-4 sleep a person requires varies considerably from night to night.
C. Substance P levels fall back to normal during periods of quiet wakeful rest even when stage-4 sleep is interrupted.
D. Anxiety increases the release of substance P even when a person is in deep sleep.
E. Stage-2 (light) sleep provides the same substance P reset that stage-4 sleep does.
(A) The conclusion that “getting sufficient stage-4 sleep is essential” hinges on the idea that nothing else can perform the same chemical reset. Choice. A states exactly that: only stage-4 sleep restores substance P to its normal level. If this statement were false—if some other process could handle the reset—stage-4 sleep would no longer be indispensable, and the argument would collapse. Therefore A is required and is the correct answer.
(B) Whether a person’s nightly quota of deep sleep changes from one night to the next does not affect the causal chain. The argument needs stage-4 sleep to be necessary, not predictable in its duration. Even if the needed amount were wildly inconsistent, the claim that it is essential could still hold. Thus B is not required.
(C) This choice asserts that quiet wakeful rest can reset substance P when deep sleep is interrupted. If C were true, stage-4 sleep would no longer be uniquely necessary, which directly contradicts the conclusion. Because an assumption must support—not undermine—the argument, C cannot be required and is therefore incorrect.
(D) The statement that anxiety increases substance P release even during deep sleep introduces a new complicating factor but leaves the central mechanism untouched. The argument does not rely on the absence of anxiety; it relies only on the presence of a unique reset during stage-4 sleep. Consequently D is irrelevant to the logic and is not an underlying assumption.
(E) By claiming that stage-2 sleep provides the same reset as stage-4 sleep, this option directly challenges the necessity of stage-4 sleep. If E were true, the conclusion would be weakened rather than supported. An assumption must be something the argument needs to remain valid, so E is not required and is incorrect.
Answer: A