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PriyankaPalit7
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12 Jun 2019, 23:24
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4. It can be concluded from the passage that COX-2 inhibitors are in danger of accidentally disrupting which of the following bodily processes?
(a) constriction of blood vessels
(b) inflammation
(c) cell division
(d) kidney function
(e) enzyme production
From paragraph 1 we get this:
"Anti-inflammatory drugs act on prostaglandins, hormone-like substances with a general regulatory role in the body – controlling blood flow to the kidneys or prompting contraction of the uterus during childbirth, for example – in addition to bearing the primary responsibility for causing pain and inflammation......"
This makes option (D) correct.
But from paragraph 2 we get:
"Although COX-2 inhibitors do in fact prevent production of prostaglandin E2 (PGE2), which is responsible for causing pain and inflammation, they also inhibit production of various other substances in the body, including prostacyclin (PGI2), which dilates blood vessels and prevents clots."
So, from the above can we not deduce that COX-2 inhibitors disrupts inflammation?
Why is option (B) not also correct then?
(a) constriction of blood vessels
(b) inflammation
(c) cell division
(d) kidney function
(e) enzyme production
From paragraph 1 we get this:
"Anti-inflammatory drugs act on prostaglandins, hormone-like substances with a general regulatory role in the body – controlling blood flow to the kidneys or prompting contraction of the uterus during childbirth, for example – in addition to bearing the primary responsibility for causing pain and inflammation......"
This makes option (D) correct.
But from paragraph 2 we get:
"Although COX-2 inhibitors do in fact prevent production of prostaglandin E2 (PGE2), which is responsible for causing pain and inflammation, they also inhibit production of various other substances in the body, including prostacyclin (PGI2), which dilates blood vessels and prevents clots."
So, from the above can we not deduce that COX-2 inhibitors disrupts inflammation?
Why is option (B) not also correct then?
12 Aug 2019, 05:42
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Researchers who developed COX-2 inhibitors hoped to avoid negative side effects by blocking only one of the two COX enzymes. After a series of trials, drugs such as Vioxx and Celebrex entered the market in the 1990s. This approach, unfortunately, soon presented its own drawbacks. Although COX-2 inhibitors do in fact prevent production of prostaglandin E2 (PGE2), which is responsible for causing pain and inflammation, they also inhibit production of various other substances in the body, including prostacyclin (PGI2), which dilates blood vessels and prevents clots.
Can't we infer from the highlighted text that COX-2 inhibitors are in danger of accidentally disrupting this process - They inhibit production of PGI2, which dilates BVs and prevents clots- Choice A ?
Can't we infer from the highlighted text that COX-2 inhibitors are in danger of accidentally disrupting this process - They inhibit production of PGI2, which dilates BVs and prevents clots- Choice A ?
11 Jul 2021, 09:23
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V04-11
C: Since you agree that this is true, how can we reject this? There is no stretch or leap required to get to this.
E: "block the production of necessary regulatory substances" is a blanket statement which I believe is not true. Moreover dilation of blood vessels and prevention of blood clots does not imply that this is necessary, more so because we know thromboxane is required to balance its actions. We would have been happy if thromboxane was also blocked. Hence, we can't say that blocking PGI-1 is good.
Statement "block the production of some regulatory substances" will also be a little stretch but better than the existing option.
C: Since you agree that this is true, how can we reject this? There is no stretch or leap required to get to this.
E: "block the production of necessary regulatory substances" is a blanket statement which I believe is not true. Moreover dilation of blood vessels and prevention of blood clots does not imply that this is necessary, more so because we know thromboxane is required to balance its actions. We would have been happy if thromboxane was also blocked. Hence, we can't say that blocking PGI-1 is good.
Statement "block the production of some regulatory substances" will also be a little stretch but better than the existing option.
