It may seem like you are going to give up tons of things. I had to rent out my house (still am renting it), my wife quit her job and had to find a new one, brought my dog to school, downsized from a 4 bedroom house to a 1 bedroom condo with the wife and dog, left friends and family, spend down savings and still took on a bunch of debt (despite a scholarship). Stopped getting to do some things that we loved.
However, it seems like you are going to give up a lot but in the end you end up gaining a lot more than you give up. My wife found a new job that she likes much more than her previous one and still works for them. We both made some of the best friends you ever could. My wife lost touch with a lot of her friends from before because she realized she had much more in common with the people we met when we were at Kellogg, are much more motivated and are more fun to be with than people who hold your success against you. We do lose a little on renting our house but in the end it is not as huge of a burden as you would think (paying a property manager is more than worth the expense).
Career wise it worked out well for both of us. Financially right now we would have been better off staying where we were but that would have been a short term thing and mainly would be due to paying down loans quickly. Last year after bonuses I made more than people three levels higher than me at my previous job, and am on a fast track compared with everyone at my company.
It might feel like you are giving tons of things up but in the end you will gain far more than you are going to give up. Whatever your situation someone has dealt with the same thing. I know people who had 5 kids, spouses who lost job, owned homes they couldnt sell and some who couldnt even rent them. I know someone who had triplets right around the start of school. Accidental pregnancies during school, divorces, broken engagements...whatever you go through you definitely wont be the first to deal with it.