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My answer is (D). It took me 01:01. Please note that option (A) does not repeat the original sentence, a surprise that should not happen in actual tests.

Original Sentence: "that will" should be "that would" because her political career is not in the simple future from year 2021. Rather, her political career was "future in the past" against her graduation speech in year 1972.
In addition, "to make" should be "making" because present participle phrase, after comma, can describe the result of the previous phrase. An infinitive phrase does not have such function. What's more, the comma is not needed for the infinitive phrase.

(A) "to make" should be "making"
(B) "will" should be "would". Also, "making" is not parallel with "span".
(C) Not a sentence.
(D) Correct version.
(E) Not a sentence thanks to the "and" in "and she". Now, both " Ellen Sirleaf Johnson delivered..." and "she initiated a political career that..." are part of the "When" subordinate clause. But there is no main / independent clause to construct a sentence.
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A) 1972, she initiated a political career that would go on to eventually span more than four decades, to make
redundancy with "go on to" and eventually. to make leads to modifier reference error(is it referring to noun/action). Eliminate

B) 1972, she initiated a political career that will eventually span more than four decades and making
Usage of and + ing verb requires parallel with initiated. 'she making her...' don't make sense. Eliminate

C) 1972, initiating a political career that will eventually span more than four decades and make
Sentence fragmentation with the usage of 'initiating'. Eliminate.

D) 1972, she initiated a political career that would eventually span more than four decades, making
Resolves all the issues with other options. Keep

E) 1972, and she initiated a political career that would eventually span more than four decades and make
'initiated' and 'make' are not parallel. Eliminate.

D is the correct answer choice.
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Correct Option D

This is one form of cause and effect kind of sentence,
a powerful speech delivered has initiated a political career, which resulted into making Ellen Sirleaf Johnson most powerful women in Africa.
This SC purely checks on Intended Meaning and tense sequence, with use of Will / Would.

When Ellen Sirleaf Johnson delivered her high school graduation speech in 1972,
she initiated a political career that will eventually span more than four decades,
to make
her one of the most powerful women in Africa.

ELimiate A, C, and E for usage of "Make"
Simply "to make" phrase is related/ indicate to future some things will happen, where else the intend of meaning says Ellen Sirleaf Johnson is already now a powerful women, so we need is a present participle or present tense to address.

A) 1972, she initiated a political career that would go on to eventually span more than four decades, to make

C) 1972, initiating a political career that will eventually span more than four decades and make
Additionally flaw with option C, is introducing present participle "Initiating" confuses and surely confirms the career span was more than 4 decades, where usage of "would" gives a probability it might have taken some more or less time close to 4 decades.

E) 1972, and she initiated a political career that would eventually span more than four decades and make
Additional Falw with option E, is too many conjuction "and" usages try to give more and more additional information makes it reducdancy, while reading its sounds not good, such as She delivered and and She initiated and make her, doent make sense.

option B, with "and making" could had been correct, but usage of "Will" demean the intended meaning for the sentence.
which is corrected in Option D and makes it flawless.
B) 1972, she initiated a political career that will eventually span more than four decades and making
D) 1972, she initiated a political career that would eventually span more than four decades, making
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