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(A) because malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues
"contrasts with" does not logically correspond with because
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(B) because of malignancy not being self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues
"contrasts with" does not logically correspond with because of
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(C) in that malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues
"in that" corresponds better with "contrast with", everything else is parallel
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(D) in that malignancy not being self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues
in that requires an independent clause
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(E) in that malignancy is not self-limited in its growth, capable of invading into adjacent tissues, and spreading to distant tissues it may be capable of
flawed parallel