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Even though this is tagged as a sub-600 question, it can pose a lot of confusion if you are not familiar with idioms that are used in comparisons.
Plus, if you are in the habit of second-guessing yourself, you might find Option B tempting.

Let’s simplify the sentence –
Withdrawal has been the crucial Leng for distinguishing X from Y drugs.
This seems to be the correct structure, so let’s hold onto Option A and have a look at the rest.

B – this is the wrong idiom. It is ‘distinguishing X from Y’. Eliminate.
C – the ‘or’ changes the meaning – addictive or non-addictive is not what is intended here. They do not mean the same thing. Eliminate.
D – the ‘or’ is not the right way to compare two items in this case. Eliminate.
E – wrong idiom again. We are trying to distinguish one thing from another. Eliminate.

Option A is the best choice.

Hope this helps!
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Dear Friends,

Here is a detailed explanation to this question-

Bunuel
Although the phenomenon of withdrawal has always been the crucial physiological Leng for distinguishing addictive from non-addictive drugs, it has become increasingly evident that not all regular heroin users experience withdrawal symptoms.


(A) addictive from

(B) addictive and

(C) addictive or

(D) between addictive or

(E) among addictive or

A: This answer choice maintains proper idiom use throughout the sentence. Thus, this answer choice is correct.

B: This answer choice utilizes the unidiomatic construction "distinguishing A and B", rather than one of the correct constructions "distinguish between A and B" and "distinguish A from B". Thus, this answer choice is incorrect.

C: This answer choice utilizes the unidiomatic construction "distinguishing A or B". Thus, this answer choice is incorrect.

D: This answer choice utilizes the unidiomatic construction "between A or B", rather than the correct construction "between A and B". Thus, this answer choice is incorrect.

E: This answer choice utilizes the unidiomatic construction "among A or B", rather than the correct construction "among A and B". Additionally, E uses the word "among" to draw a distinction between two nouns "addictive drugs" and "non-addictive drugs". Thus, this answer choice is incorrect.

Hence, A is the best answer choice.

To understand the concept of "Use of Distinguish on GMAT", you may want to watch the following video (~1 minute):


To understand the concept of "Between v/s Among on GMAT", you may want to watch the following video (~1 minute):


All the best!
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