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555-605 Level|   Strengthen|                     
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Conclusion - Antibodies to herpesvirus causes keratitis.
Type - Strengthen

(A) Other types of virus have surface proteins that closely resemble proteins found in various organs of mice - Okay that probably explains other types of degenerative diseases the mices might be affected by, but doensn't do squat to explain cause of keratitis in the eye. Drop

(B) Mice that are infected with the herpesvirus but do not develop keratitis produce as many antibodies as infected mice that do develop keratitis. This weakens the conclusion. How? If the antibodies post infection produced are the same in number in both types of mice, then the antibodies are not the differentiating factor leading to keratitis. Of course, we're not interested in an option that hurts the passage. Drop

(C) Mice infected with a new strain of the herpesvirus that has different surface proteins did not develop keratitis. - No cause, no effect. This does strengthen. Simple and neat. Keep

(D) Mice that have never been infected with the herpesvirus can sometimes develop keratitis. - Okay, but can this co-exist with the conclusion above, i.e., "Antibodies to herpes viruses generally cause keratitis.". Yes. This form of degenerative disease could have multiple causes, antibodies to herpesvirus being one of them. However, does this support that herpesvirus is one of the causes. Not really. Drop

(E) There are mice that are unable to form antibodies in response to herpes infections, and these mice contract herpes at roughly the same rate as other mice. - This might tell us that ability to form antibodies to a herpes infection is not a factor in preventing the infection in the first place, since the rate of infection is the same. Good. Does it tell us the cause of keratitis. Not a single mention in the option. Drop­
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I interpreted the conclusion as "scientists hypothesize that these cases of keratitis are caused by antibodies to the herpesvirus, in general", meaning any antibodies cause keratitis. This is because the conclusion didn't specify which antibodies it is referring to.

Hence I eliminated B because while it is a new antibody, it belongs to the universe of antibodies causing keratitis. Why is this wrong?
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Hi,

I've a question regarding the OA. Doesn't the OA assume that the antibodies automatically tend to change with the different strain of the herpesvirus?
The OA doesn't assume the antibodies change when the mouse contracts the new strain of herpesvirus.

The mouse's immune system will produce a set of antibodies that help fight a virus. If a new strain of herpesvirus is given to the mouse, the mouse will produce a new (and potentially different) set of antibodies.

These new antibodies will match different proteins to the antibodies for the original herpesvirus. This means the new antibodies may not bind to the proteins on the surface of cells in the part of the mouse's eye that is susceptible to keratitis. If the antibodies are unable to bind to these proteins, the mouse will not develop keratitis from the new antibodies.

This helps support the scientists' reasoning that it is the antibodies to the original strain of herpesvirus that are causing keratitis in mice. This is because it is the similarity between the surface protein on the original strain of herpesvirus and the cells in the mouse's eye that causes the problem. This similarity makes the mouse susceptible to keratitis by the antibodies binding to the surface protein in its eye.

I hope that helps!
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soniasw16
I interpreted the conclusion as "scientists hypothesize that these cases of keratitis are caused by antibodies to the herpesvirus, in general", meaning any antibodies cause keratitis. This is because the conclusion didn't specify which antibodies it is referring to...
Actually, the conclusion does specify which antibodies it is referring to: "scientists hypothesize that these cases of keratitis are caused by antibodies to the herpesvirus." If any type of antibodies could cause keratitis, the part in bold would not be there.

I hope that helps a bit!
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