I would go with C on this one.
It is difficult to say precisely how many species of insects there are on Earth, in part because it is often hard to distinguish between a separate species and a variety of one, but scientists who have to give an estimate usually place the number at around 950,000 unique species.
A. and a variety of one, but scientists who have to give an estimate usually place
B. and a variety of them, with scientists having to give an estimate usually placing
C. and a variety of one, but scientists who give an estimate usually placed
D. or a variety of them, but scientists who have given an estimate usually placed
E. or a variety of them, but scientists who have an estimate to give usually placing
we need between and contruction so D and E are out.
"them" in B looks ambiguous as it can be either (a separate species and variety of species of insects) or (separate species and variety of species within those in separate species)
Secondly scientists who have to sounds as if they are forced to give a number - I mean it sounds kinda awkward to say that way.
Therefore I would go with C.