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505-555 Level|   Science|   Short Passage|                                    
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GMATNinja MagooshExpert : Question number 5: I understand that (A) is correct. But what is the problem with (C)?
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Although I see why A is the least crappy option on the last question, I think it is quite a gap to go from "not strictly required for their trials" to "likely to be irrelevant".
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GMATNinja MagooshExpert : Question number 5: I understand that (A) is correct. But what is the problem with (C)?

The problem with C is the word "avoid". You can never completely avoid overlooking variables that may affect the outcome. If it would have been modified something like "avoid some of" then it could have been the correct answer.
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Passage: Clinical Trials

Question: Patient Categories

The Simple Story

Frazier and Mosteller propose that changing clinical trials could improve medical research. They propose two specific changes. First, they suggest limiting the amount of data collected about patients to save costs. Second, they suggest enrolling more patients in trials to obtain a more representative sample of patients.

Sample Passage Map

Here is one way to map this passage. (Note: abbreviate as desired!)

F+M: change clin trials

1) Less data à save $

2) More patients à more represent

Step 1: Identify the Question

The word inferred in the question stem indicates that this is an Inference question.

Step 2: Find the Support

This question refers to specific lines of text. Start by reading the sentence containing the specified lines. Read the preceding or following sentences if necessary.

“Often researchers restrict study participants to patients who have no ailments besides those being studied. A treatment judged successful under these ideal conditions can then be evaluated under normal conditions.”

Step 3: Predict an Answer

The answer should focus on what can be learned from a study on the patients with no other ailments. The second sentence above suggests that just because positive results are found in these patients does not mean that there will be positive results in all patients (additional evaluation is needed for the broader group of patients).

Step 4: Eliminate and Find a Match

(A) CORRECT. Even if treatments are deemed successful in this smaller patient group, it is not certain they will work for all types of patients; in other words, the findings have limited applicability.

(B) The ideal conditions referred to in the second quoted sentence are actually the conditions created by including the specified patient group.

(C) This answer is contradicted by information in the passage; this patient group is not representative of all patients.

(D) Limiting data collection is primarily discussed in the first paragraph of the passage, not related to this patient group.

(E) Specific concerns related to progressive disease are discussed near the end of the passage, not in relation to this patient group. Additionally, the passage suggests that a diverse group of patients may be especially important for progressive diseases.
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Question number 5:
I chose C

In option A, nowhere in the first paragraph has it been mentioned or trying to mean that "information likely to be irrelevant to the study". Even from the statement "Only in research on entirely new treatments are new and unexpected variables likely to arise.", one cannot deduce the fact that "information likely to be irrelevant to the study"

I chose C because from the statement "Although limiting information collection could increase the risk that researchers will overlook facts relevant to a study", we can understand that the researchers could be trying to overlook facts relevant to a study by collection more information.

Please explain where is my understanding wrong.
Quote:
5. According to the passage, which of the following describes a result of the way in which researchers generally conduct clinical trials?

(A) They expend resources on the storage of information likely to be irrelevant to the study they are conducting.

(B) They sometimes compromise the accuracy of their findings by collecting and analyzing more information than is strictly required for their trials.

(C) They avoid the risk of overlooking variables that might affect their findings, even though doing so raises their research costs.

(D) Because they attempt to analyze too much information, they overlook facts that could emerge as relevant to their studies.

(E) In order to approximate the conditions typical of medical treatment, they base their methods of information collection on those used by hospitals.
As described towards the end of this post, collecting extra information will never eliminate the risk of overlooking facts relevant to the study.

So even though researchers currently collect far more background information on patients than is strictly required, they do not avoid the risk of overlooking variables that might affect their findings. According to the passage, no matter how much information is collected, that risk will never be eliminated. So (E) is not correct.

As for choice (A), we are specifically told that "researchers collect far more background information on patients than is strictly required for their trials." From that, we can immediately infer that they collect information that is not needed and thus likely to be irrelevant.

Taking it a bit further, according to the author, "limiting information collection could increase the risk that researchers will overlook facts relevant to a study." However, even if information collection is reduced, the risk of overlooking facts relevant to the study will still be small. This suggests that increasing the amount of information collected does NOT significantly decrease the risk of overlooking facts relevant to the study.

So we can infer that increasing the amount of information collected would not significantly increase the amount of relevant data. This implies that most of the additional information is irrelevant.

In other words, if you increase the amount of information collected, most of it will likely be irrelevant. Thus, most of that information is LIKELY to be irrelevant to the study.

I hope that helps!

How "limiting information collection could increase the risk that researchers will overlook facts relevant to a study." However, even if information collection is reduced, the risk of overlooking facts relevant to the study will still be small. implies to ...
"" This suggests that increasing the amount of information collected does NOT significantly decrease the risk of overlooking facts relevant to the study.
So we can infer that increasing the amount of information collected would not significantly increase the amount of relevant data. This implies that most of the additional information is irrelevant.
In other words, if you increase the amount of information collected, most of it will likely be irrelevant. Thus, most of that information is LIKELY to be irrelevant to the study. "" ?
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This is regarding question 100.

Option C states that it is best way to sample total population of potential participants.

Can't we conclude C from lines 18-20, stating that "researchers enrol.... Thereby obtaining a more representative sample ".

I got trapped in option A and C, finally selected C because option A mention about " limited applicability of findings" while lines 18-21 only talks about "MORE representative sample"????

This does not mean that findings are of limited applicability.

Could someone please explain to me.
Actually Question 100 clearly asks us to limit ourselves to "bold section" (lines 21-23) and what is the "inference" of these lines, according to the passage. According to the passage, because researchers "restrict" study participation to only "certain" patients, this is "not" enabling researchers to evaluate a treatment's efficacy for diverse patients under various conditions and to evaluate its effectiveness for different patient subgroups.

This clearly means that currently, the findings of the research have limited applicability. This is what A says.

Coming to C, it says that "it would be the best way to sample the total population of potential patients". One thing that struck me about this optio was the term: "potential" patients. Not sure what "potential" means; my understanding is that "potential" patients would mean people who currently are not patients (means they do have a disease currently), but have a "potential" (say "genetically") to develop that disease. But, there is nothing about "potential patients" metnioned in the passage.

What do you think about this?

Sure, I'd be happy to offer you some guidance, vikasbansal227.

Here's the issue: it's critical to understand which party question 100 is asking us to make an inference about. Is is Frazier & Mosteller's proposal, or the traditional way?

Frazier and Mosteller propose not only that researchers limit data collection on individual patients but also that researchers enroll more patients in clinical trials, thereby obtaining a more representative sample of the total population with the disease under study. Often researchers restrict study participation to patients who have no ailments besides those being studied.

Question 100 is actually asking about the current, or traditional way of designing clinical trials. Now, given that the traditional way of building a sample in a clinical trial is to often "restrict study participation to patients who have no ailments besides those being studied". Take a look at the difference between A and C in that light:

100) Which of the following can be inferred from the passage about a study of the category of patients referred to in lines 21-23 (bold section)?
(A) Its findings might have limited applicability.

If the results only relate to those suffering from an ailment rather than the population in general, then it's findings MIGHT (key inference question word) have limited applicability. That has to be true. 100%

(C) It would be the best way to sample the total population of potential patients.
This is a trap answer for those who think question 100 is asking us about the Frazier and Mosteller proposal, but as we know, it's not. According to the passage, we can't infer that the traditional way of conducting clinical trials is THE BEST WAY to sample the total population of POTENTIAL patients, because the traditional approach is only to sample those with the illness. That wouldn't include POTENTIAL patients.. Get rid of C.

EMPOWERgmatVerbal
Thank you for this helpful explanation. To clarify on #566 (which of the following can be inferred from the passage about a study of the category of patients referred to in lines 20-22), Choice E is incorrect because the passage does not distinguish between nonprogressive vs progressive diseases right?
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woohoo921
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vikasbansal227
This is regarding question 100.

Option C states that it is best way to sample total population of potential participants.

Can't we conclude C from lines 18-20, stating that "researchers enrol.... Thereby obtaining a more representative sample ".

I got trapped in option A and C, finally selected C because option A mention about " limited applicability of findings" while lines 18-21 only talks about "MORE representative sample"????

This does not mean that findings are of limited applicability.

Could someone please explain to me
Actually Question 100 clearly asks us to limit ourselves to "bold section" (lines 21-23) and what is the "inference" of these lines, according to the passage. According to the passage, because researchers "restrict" study participation to only "certain" patients, this is "not" enabling researchers to evaluate a treatment's efficacy for diverse patients under various conditions and to evaluate its effectiveness for different patient subgroups.

This clearly means that currently, the findings of the research have limited applicability. This is what A says.

Coming to C, it says that "it would be the best way to sample the total population of potential patients". One thing that struck me about this optio was the term: "potential" patients. Not sure what "potential" means; my understanding is that "potential" patients would mean people who currently are not patients (means they do have a disease currently), but have a "potential" (say "genetically") to develop that disease. But, there is nothing about "potential patients" metnioned in the passage.

What do you think about this?

Sure, I'd be happy to offer you some guidance, vikasbansal227.

Here's the issue: it's critical to understand which party question 100 is asking us to make an inference about. Is is Frazier & Mosteller's proposal, or the traditional way?

Frazier and Mosteller propose not only that researchers limit data collection on individual patients but also that researchers enroll more patients in clinical trials, thereby obtaining a more representative sample of the total population with the disease under study. Often researchers restrict study participation to patients who have no ailments besides those being studied.

Question 100 is actually asking about the current, or traditional way of designing clinical trials. Now, given that the traditional way of building a sample in a clinical trial is to often "restrict study participation to patients who have no ailments besides those being studied". Take a look at the difference between A and C in that light:

100) Which of the following can be inferred from the passage about a study of the category of patients referred to in lines 21-23 (bold section)?
(A) Its findings might have limited applicability.

If the results only relate to those suffering from an ailment rather than the population in general, then it's findings MIGHT (key inference question word) have limited applicability. That has to be true. 100%

(C) It would be the best way to sample the total population of potential patients.
This is a trap answer for those who think question 100 is asking us about the Frazier and Mosteller proposal, but as we know, it's not. According to the passage, we can't infer that the traditional way of conducting clinical trials is THE BEST WAY to sample the total population of POTENTIAL patients, because the traditional approach is only to sample those with the illness. That wouldn't include POTENTIAL patients.. Get rid of C.

EMPOWERgmatVerbal
Thank you for this helpful explanation. To clarify on #566 (which of the following can be inferred from the passage about a study of the category of patients referred to in lines 20-22), Choice E is incorrect because the passage does not distinguish between nonprogressive vs progressive diseases right?


Dear woohoo921
you are right, and thus we cannot infer how such variable will affect the treatment.
The way to solve such questions is to look once sentence above and below the alluded point and to get insight how they are bound.

The lines 20 - 22 [Often researchers restrict study participation to patients who have no ailments besides those being studied.] illustrates example of limitations mentioned in the previous assertion: Frazier and Mosteller propose not only that researchers limit data collection on individual patients but also that researchers enroll more patients in clinical trials, thereby obtaining a more representative sample...
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Frazier and Mosteller assert that medical research could be improved by a move toward larger, simpler clinical trials of medical treatments. Currently, researchers collect far more background information on patients than is strictly required for their trials — substantially more than hospitals collect — thereby escalating costs of data collection, storage, and analysis. Although limiting information collection could increase the risk that researchers will overlook facts relevant to a study, Frazier and Mosteller contend that such risk, never entirely eliminable from research, would still be small in most studies. Only in research on entirely new treatments are new and unexpected variables likely to arise.

Frazier and Mosteller propose not only that researchers limit data collection on individual patients but also that researchers enroll more patients in clinical trials, thereby obtaining a more representative sample of the total population with the disease under study. Often researchers restrict study participation to patients who have no ailments besides those being studied. A treatment judged successful under these ideal conditions can then be evaluated under normal conditions. Broadening the range of trial participants, Frazier and Mosteller suggest, would enable researchers to evaluate a treatment’s efficacy for diverse patients under various conditions and to evaluate its effectiveness for different patient subgroups. For example, the value of a treatment for a progressive disease may vary according to a patient’s stage of disease. Patients’ ages may also affect a treatment’s efficacy.

1. The passage is primarily concerned with

(A) identifying two practices in medical research that may affect the accuracy of clinical trials

(B) describing aspects of medical research that tend to drive up costs

(C) evaluating an analysis of certain shortcomings of current medical research practices

(D) describing proposed changes to the ways in which clinical trials are conducted

(E) explaining how medical researchers have traditionally conducted clinical trials and how such trials are likely to change


2. Which of the following can be inferred from the passage about a study of the category of patients referred to in lines 20 - 22 [Often researchers restrict study participation to patients who have no ailments besides those being studied.]?

(A) Its findings might have limited applicability.

(B) It would be prohibitively expensive in its attempt to create ideal conditions.

(C) It would be the best way to sample the total population of potential patients.

(D) It would allow researchers to limit information collection without increasing the risk that important variables could be overlooked.

(E) Its findings would be more accurate if it concerned treatments for a progressive disease than if it concerned treatments for a nonprogressive disease.


3. It can be inferred from the passage that a study limited to patients like those mentioned in lines 20-22 [Often researchers restrict study participation to patients who have no ailments besides those being studied.] would have which of the following advantages over the kind of study proposed by Frazier and Mosteller?

(A) It would yield more data and its findings would be more accurate.

(B) It would cost less in the long term, though it would be more expensive in its initial stages.

(C) It would limit the number of variables researchers would need to consider when evaluating the treatment under study.

(D) It would help researchers to identify subgroups of patients with secondary conditions that might also be treatable.

(E) It would enable researchers to assess the value of an experimental treatment for the average patient.


4. The author mentions patients' ages primarily in order to

A. identify the most critical variable differentiating subgroups of patients

B. cast doubt on the advisability of implementing Frazier and Mosteller's proposals about medical research

C. indicate why progressive diseases may require different treatments at different stages

D. illustrate a point about the value of enrolling a wide range of patients in clinical trials

E. substantiate an argument about the problems inherent in enrolling large numbers of patients in clinical trials


5. According to the passage, which of the following describes a result of the way in which researchers generally conduct clinical trials?

(A) They expend resources on the storage of information likely to be irrelevant to the study they are conducting.

(B) They sometimes compromise the accuracy of their findings by collecting and analyzing more information than is strictly required for their trials.

(C) They avoid the risk of overlooking variables that might affect their findings, even though doing so raises their research costs.

(D) Because they attempt to analyze too much information, they overlook facts that could emerge as relevant to their studies.

(E) In order to approximate the conditions typical of medical treatment, they base their methods of information collection on those used by hospitals.



RC00312-01
RC00312-03
RC00312-04
RC00312-05
RC00312-06


Hi Brent BrentGMATPrepNow, for question 4, Since it stated

to evaluate its effectiveness for different patient subgroups. For example, the value of a treatment for a progressive disease may vary according to a patient’s stage of disease. Patients’ ages may also affect a treatment’s efficacy.

So both progressive disease and Patients’ ages are subgroups in order for effectiveness, so not sure why C is not right?
Checking on OG's explanation doesn't make much sense either. Could you shed your insight here please? Thanks Brent
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In question 4 why not E? Why D?
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snehaag
In question 4 why not E? Why D?
­Posted here: 
https://gmatclub.com/forum/frazier-and- ... l#p1623609

D is correct, as both of these examples, including age, are used to highlight how the F&M approach can help uncover information about a broader range of patients.

E. is the opposite. The author uses the age example to point out a potential benefit of F&M---not to provide proof of an argument against F&M. Nonsense. We can tell the author did the opposite.

Also posted here the OE

https://gmatclub.com/forum/frazier-and- ... l#p2601825
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Question 1: Correct Answer - (D) describing proposed changes to the ways in which clinical trials are conducted
Explanation for Eliminating Other Options:
  • (A) identifying two practices in medical research that may affect the accuracy of clinical trials
    • The passage primarily discusses proposed changes to clinical trials rather than focusing on accuracy-related practices. While accuracy is a concern, the emphasis is on efficiency and broadening patient participation.
  • (B) describing aspects of medical research that tend to drive up costs
    • Although the passage mentions costly data collection, its main focus is not on costs but on improving clinical trial design.
  • (C) evaluating an analysis of certain shortcomings of current medical research practices
    • The passage does discuss shortcomings, but it does not critically evaluate them. Instead, it presents solutions to improve clinical trials.
  • (E) explaining how medical researchers have traditionally conducted clinical trials and how such trials are likely to change
    • The passage does not provide a historical overview of clinical trials. Instead, it focuses on specific proposed changes rather than a before-and-after comparison.
Thus, (D) is the best choice ✅ as the passage primarily discusses proposed modifications to clinical trial procedures to make them larger and simpler.

Question 2: Correct Answer - (A) Its findings might have limited applicability.
Explanation for Eliminating Other Options:
  • (A) Its findings might have limited applicability.(Correct)
    • The passage states that researchers often restrict study participation to patients with no other ailments besides the one being studied. This creates ideal conditions, but such a study may not reflect how the treatment works for the broader patient population, making its findings less applicable in real-world settings.
  • (B) It would be prohibitively expensive in its attempt to create ideal conditions.
    • The passage does not suggest that such studies are prohibitively expensive. The discussion of costs is related to data collection, not the selection of patients.
  • (C) It would be the best way to sample the total population of potential patients.
    • The passage argues the opposite: that including more diverse patients would lead to better representation of the total population.
  • (D) It would allow researchers to limit information collection without increasing the risk that important variables could be overlooked.
    • The passage states that limiting data collection does carry a risk of missing relevant factors, even if the risk is generally small.
  • (E) Its findings would be more accurate if it concerned treatments for a progressive disease than if it concerned treatments for a nonprogressive disease.
    • The passage does mention progressive diseases but does not compare the accuracy of studies between progressive and nonprogressive diseases.

Question 3: Correct Answer - (C) It would limit the number of variables researchers would need to consider when evaluating the treatment under study.
Explanation for Eliminating Other Options:
  • (A) It would yield more data and its findings would be more accurate.
    • The passage suggests that restricting participants creates ideal conditions, but it does not necessarily lead to more data or increased accuracy in real-world applications.
  • (B) It would cost less in the long term, though it would be more expensive in its initial stages.
    • The passage does not compare the long-term vs. short-term costs of different study designs.
  • (C) It would limit the number of variables researchers would need to consider when evaluating the treatment under study.(Correct)
    • By selecting only patients without other ailments, researchers can control for fewer variables, making the study simpler in terms of analysis. This aligns with the reasoning in the passage.
  • (D) It would help researchers to identify subgroups of patients with secondary conditions that might also be treatable.
    • The restricted study design excludes patients with secondary conditions, so it would not help identify how such patients respond to treatment.
  • (E) It would enable researchers to assess the value of an experimental treatment for the average patient.
    • The passage argues that such studies are not representative of the average patient, as they exclude those with other conditions.

Question 4: Correct Answer - (D) illustrate a point about the value of enrolling a wide range of patients in clinical trials
Explanation for Eliminating Other Options:
  • (A) identify the most critical variable differentiating subgroups of patients
    • The passage mentions age as one of several factors affecting treatment efficacy, not as the most critical variable.
  • (B) cast doubt on the advisability of implementing Frazier and Mosteller's proposals about medical research
    • The passage does not present age as an argument against their proposals; instead, it supports their argument by highlighting the benefits of diverse patient participation.
  • (C) indicate why progressive diseases may require different treatments at different stages
    • While the passage does mention progressive diseases, it does so separately from the discussion on age. The reference to age is used to support the idea that diverse patients should be included in trials.
  • (D) illustrate a point about the value of enrolling a wide range of patients in clinical trials(Correct)
    • The passage states that age may affect a treatment’s efficacy, reinforcing the argument that trials should include diverse patient groups.
  • (E) substantiate an argument about the problems inherent in enrolling large numbers of patients in clinical trials
    • The passage advocates for enrolling more patients rather than highlighting problems with doing so.
Thus, (D) is correct because the mention of age serves to highlight why a diverse sample of patients is important in clinical trials.


Question 5: Correct Answer - (A) They expend resources on the storage of information likely to be irrelevant to the study they are conducting.
Explanation for Eliminating Other Options:
  • (A) They expend resources on the storage of information likely to be irrelevant to the study they are conducting.(Correct)
    • The passage states that researchers collect far more background information than hospitals do, leading to higher costs for data collection, storage, and analysis. This aligns perfectly with this answer choice.
  • (B) They sometimes compromise the accuracy of their findings by collecting and analyzing more information than is strictly required for their trials.
    • While the passage mentions that excessive data collection increases costs, it does not claim that it compromises accuracy.
  • (C) They avoid the risk of overlooking variables that might affect their findings, even though doing so raises their research costs.
    • The passage acknowledges that some risk of overlooking variables always exists, meaning that researchers do not completely eliminate this risk.
  • (D) Because they attempt to analyze too much information, they overlook facts that could emerge as relevant to their studies.
    • The passage does not state that excessive data collection causes important facts to be overlooked.
  • (E) In order to approximate the conditions typical of medical treatment, they base their methods of information collection on those used by hospitals.
    • The passage states the opposite—that researchers collect more data than hospitals, meaning their methods are not based on hospital practices.
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