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# In clinical trials of new medicines, half of the subjects

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Director
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In clinical trials of new medicines, half of the subjects [#permalink]

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25 May 2005, 09:05
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18. In clinical trials of new medicines, half of the subjects receive the drug being tested and half receive a physiologically inert substanceâ€”a placebo. Trials are designed with the intention that neither subjects nor experimenters will find out which subjects are actually being given the drug being tested. However, this intention is frequently frustrated because______

Which one of the following, if true, most appropriately completes the explanation?

(A) often the subjects who receive the drug being tested develop symptoms that the experimenters recognize as side effects of the physiologically active drug
(B) subjects who believe they are receiving the drug being tested often display improvements in their conditions regardless of whether what is administered to them is physiologically active or not
(C) in general, when the trial is intended to establish the experimental drugâ€™s safety rather than its effectiveness, all of the subjects are healthy
(D) when a trial runs a long time, few of the experimenters will work on it from inception to conclusion
(E) the people who are subjects for clinical trials must, by law, be volunteers and must be informed of the possibility that they will receive a placebo
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25 May 2005, 14:17
E
Senior Manager
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25 May 2005, 14:41
guess E.
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26 May 2005, 06:41
Looks B to me
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26 May 2005, 07:12
I pick B.
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26 May 2005, 07:22
A

....Trials are designed with the intention that neither subjects nor experimenters will find out ....

A reveals who receives what, hence frustrating.
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26 May 2005, 07:31
(A).

Not (B), because if takers of both the placebo and the real drug show improvements, that does not reveal who took which.

Not (E), becuase if the law required that test volunteers be told they were taking a real drug, then the trials would not be "designed with the intention that neither subjects nor experimenters will find out which subjects are actually being given the drug".
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26 May 2005, 07:38
A...

intention: neither subjects nor experimenter should know who is being given what.
intention frustrated: means that the subject and/or experimenter get to know
who is given what.

(A) often the subjects who receive the drug being tested develop symptoms that the experimenters recognize as side effects of the physiologically active drug
satisfies intention frustrated

(B) subjects who believe they are receiving the drug being tested often display improvements in their conditions regardless of whether what is administered to them is physiologically active or not
could be what is called placebo effect.

(C) in general, when the trial is intended to establish the experimental drugâ€™s safety rather than its effectiveness, all of the subjects are healthy
?

(D) when a trial runs a long time, few of the experimenters will work on it from inception to conclusion
?

(E) the people who are subjects for clinical trials must, by law, be volunteers and must be informed of the possibility that they will receive a placebo
"of the possibility" implies that the volunteers will not know for sure whether they are given
placebo or not... hence does intention frustrated does not seem to be satisfied.
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26 May 2005, 10:27
kamal_tejnani wrote:
A...

intention: neither subjects nor experimenter should know who is being given what.
intention frustrated: means that the subject and/or experimenter get to know
who is given what.

(A) often the subjects who receive the drug being tested develop symptoms that the experimenters recognize as side effects of the physiologically active drug
satisfies intention frustrated

I vote for A.

B-would have been the right choice , if it were asked as to what caused frustration to the experiment, but here the intention is being frustrated as the secrecy is being compromised.

HMTG.
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26 May 2005, 11:54
it should be A, don't know why I chose E
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26 May 2005, 17:12
The OA is A.
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# In clinical trials of new medicines, half of the subjects

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