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Sub 505 Level|   Complete the Passage|                     
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Active GMAT Club Expert! Tag them with @ followed by their username for a faster response.
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time taken 2:58

I got the answer via POE

We need to show why leptin can't be used as a dietary supplement...

B. there are pharmaceuticals already available that can contribute to weight loss by speeding up the metabolism
out of scope, even if there are other pharmaceuticals, that doesn't answer why leptin can't be used as a dietary supplement.

C. people with unusually low levels of leptin in their blood tend to have a high percentage of body fat
out of scope, even if they do have high percentage of body fat, this doesn't tell us why leptin won't help reduce that fat...

D. the mice that do not naturally produce leptin were from a specially bred strain of mice
so what? out of scope

E. mice whose bodies did produce leptin also lost some of their body fat when given leptin injections
this tells us a case in which leptin has helped in reducing body fat, doesn't address the issue at hand.

hence via POE answer is A

strange but I feel I've seen this question before :/
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pre-think - We need to tell why leptin can't be used as dietary substance. Well we know that when injected direct in blood it is working as intended but taking is as diet its not working. it means something in b/w in working on it. in this case A is explaining in perfect way. A must be the answer.


A. the digestive system breaks down proteins before they can enter the bloodstream
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Bunuel
Which of the following most logically completes the passage?

Leptin, a protein occurring naturally in the blood, appears to regulate how much fat the body carries by speeding up the metabolism and decreasing the appetite when the body has too much fat. Mice that do not naturally produce leptin have more fat than other mice, but lose fat rapidly when they are given leptin injections. Unfortunately, however, leptin cannot be used as a dietary supplement to control fat, since __________.


A. the digestive system breaks down proteins before they can enter the bloodstream

B. there are pharmaceuticals already available that can contribute to weight loss by speeding up the metabolism

C. people with unusually low levels of leptin in their blood tend to have a high percentage of body fat

D. the mice that do not naturally produce leptin were from a specially bred strain of mice

E. mice whose bodies did produce leptin also lost some of their body fat when given leptin injections



NEW question from GMAT® Official Guide 2019


(CR04159)


Argument: Leptin, a protein found in blood, appears to regulate fat. But leptin cannot be used as a dietary supplement to control fat because __________

We are looking for a choice that shows despite consuming leptin, it will not regulate fat. Option A states that digestive system will break it down. Thus it's the answer we are looking for.
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Leptin, a protein occurring naturally in the blood, appears to regulate how much fat the body carries by speeding up the metabolism and decreasing the appetite when the body has too much fat. Mice that do not naturally produce leptin have more fat than other mice, but lose fat rapidly when they are given leptin injections. Unfortunately, however, leptin cannot be used as a dietary supplement to control fat, since __________.


A. the digestive system breaks down proteins before they can enter the bloodstream - Correct -- so injection works but eating won't

B. there are pharmaceuticals already available that can contribute to weight loss by speeding up the metabolism -- Irrelevant

C. people with unusually low levels of leptin in their blood tend to have a high percentage of body fat -- Incorrect - this does not explain why leptin CANNOT be used as a dietary supplement to control fat

D. the mice that do not naturally produce leptin were from a specially bred strain of mice -- Irrelevant

E. mice whose bodies did produce leptin also lost some of their body fat when given leptin injections -- Incorrect -- this says that Leptin is effective to a certain extent even when one produces it

Answer A
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Bunuel
Which of the following most logically completes the passage?

Leptin, a protein occurring naturally in the blood, appears to regulate how much fat the body carries by speeding up the metabolism and decreasing the appetite when the body has too much fat. Mice that do not naturally produce leptin have more fat than other mice, but lose fat rapidly when they are given leptin injections. Unfortunately, however, leptin cannot be used as a dietary supplement to control fat, since __________.


(A) the digestive system breaks down proteins before they can enter the bloodstream

(B) there are pharmaceuticals already available that can contribute to weight loss by speeding up the metabolism

(C) people with unusually low levels of leptin in their blood tend to have a high percentage of body fat

(D) the mice that do not naturally produce leptin were from a specially bred strain of mice

(E) mice whose bodies did produce leptin also lost some of their body fat when given leptin injections



NEW question from GMAT® Official Guide 2019


(CR04159)

Step 1: Identify the Question

The argument contains a blank space, and the question asks which answer choice most logically completes the passage. Fill-in-the-blank questions are typically Strengthen questions; however, to be sure of what problem type this is, read it and determine the logical relationship between the blank and the rest of the passage.

Step 2: Deconstruct the Argument

L: regulates fat (met. ↑, app. ↓)

Mice w/ no L: fat ↑, BUT L injections → fat ↓

BUT: L not a dietary supp. for fat, b/c ??????

The first part of the argument describes the fat-regulating properties of leptin. It appears to reduce fat when injected into mice. But, there’s a catch: surprisingly, it can’t be used as a dietary supplement. The argument doesn’t explain why this is; instead, that section is left blank. Because you’re asked to explain a surprising fact with no prior evidence, treat this as an Explain the Discrepancy problem.

Step 3: Pause and State the Goal

On Explain the Discrepancy problems, the right answer will give a reason for the surprising phenomenon to have occurred. In this case, the right answer needs to give a valid reason that leptin can’t be used as a dietary supplement.

Step 4: Work from Wrong to Right

(A) CORRECT. This explains why leptin can’t be used as a dietary supplement: if it’s eaten, it is broken down by the digestive system and can’t enter the bloodstream. Therefore, it would be ineffective. This is consistent with the statements in the argument: leptin naturally occurs in the blood, and is effective when injected.

(B) The surprise in this argument is specifically that leptin is ineffective. Whether other pharmaceuticals have similar effects doesn’t bear on whether leptin itself is effective.

(C) If anything, this suggests that leptin is a useful supplement, which is the opposite of what the right answer should do. However, it also doesn’t directly relate to the argument, since it doesn’t clarify whether leptin is an effective supplement—it only describes naturally occurring leptin.

(D) The mice in the experiment were injected with leptin, not given leptin as a dietary supplement. Therefore, information about the mice doesn’t help determine whether leptin is effective as a dietary supplement.

(E) The mice in the experiment were injected with leptin, not given leptin as a dietary supplement. Therefore, information about the mice doesn’t help determine whether leptin is effective as a dietary supplement. Additionally, this suggests, if anything, that leptin is effective, which is the opposite of what the right answer should do.







Ok look guys, I know that the option A will take a lot of time to process and understand that leptin occurs in blood and since break down happens before that protein doesn't reach blood.

That is ok if you got it,

if you don't understand that, skip the option and look at B,C,D,E
It is easier to understand and eliminate them

REMEMBER
On GMAT if one option is wayyyy to technical to understand, try to eliminate the others, this way, you get to be the boss, and avoid the unnecessary waste of time.\

If you find two option that you do not understand, either skip the question or, if you can, take about a minute more and solve it
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I agree with what Businessconquerer said. If you can't get you logic straight when working on technical answer choices like A, simply skip it and see if POE can help you.

Here is my 2 cents for choosing A anyways:

If digestive system breaks down protein, so it does to Leptin (also a protein). Therefore, Leptin can never reach bloodstream, and doesn't have any effects. Why? From the passage, we know that mice are given leptin injections, and we know injections work by going into the bloodstream.
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Which of the following most logically completes the passage?

Leptin, a protein occurring naturally in the blood, appears to regulate how much fat the body carries by speeding up the metabolism and decreasing the appetite when the body has too much fat. Mice that do not naturally produce leptin have more fat than other mice, but lose fat rapidly when they are given leptin injections. Unfortunately, however, leptin cannot be used as a dietary supplement to control fat, since __________.


(A) the digestive system breaks down proteins before they can enter the bloodstream
Correct. However, note that this choice does have a flaw. The assumption being made here is that leptin, a protein naturally occurring in the blood, must also function in the blood. Is it likely the case? Yes…but we don’t actually have further information to tell us about the complex signalling pathways …maybe there are other alternative pathways that leptin can exert its effects.

(B) there are pharmaceuticals already available that can contribute to weight loss by speeding up the metabolism X
-Does not explain why leptin cannot be used as a supplement

(C) people with unusually low levels of leptin in their blood tend to have a high percentage of body fat X
-This just gives us a little more detail about what is already known in the passsage

(D) the mice that do not naturally produce leptin were from a specially bred strain of mice X
-besides the point

(E) mice whose bodies did produce leptin also lost some of their body fat when given leptin injections X
-Validates the function of leptin, but sidesteps the issue of leptin as a supplement
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CEdward
Which of the following most logically completes the passage?

Leptin, a protein occurring naturally in the blood, appears to regulate how much fat the body carries by speeding up the metabolism and decreasing the appetite when the body has too much fat. Mice that do not naturally produce leptin have more fat than other mice, but lose fat rapidly when they are given leptin injections. Unfortunately, however, leptin cannot be used as a dietary supplement to control fat, since __________.


(A) the digestive system breaks down proteins before they can enter the bloodstream
Correct. However, note that this choice does have a flaw. The assumption being made here is that leptin, a protein naturally occurring in the blood, must also function in the blood. Is it likely the case? Yes…but we don’t actually have further information to tell us about the complex signalling pathways …maybe there are other alternative pathways that leptin can exert its effects.

(B) there are pharmaceuticals already available that can contribute to weight loss by speeding up the metabolism X
-Does not explain why leptin cannot be used as a supplement

(C) people with unusually low levels of leptin in their blood tend to have a high percentage of body fat X
-This just gives us a little more detail about what is already known in the passsage

(D) the mice that do not naturally produce leptin were from a specially bred strain of mice X
-besides the point

(E) mice whose bodies did produce leptin also lost some of their body fat when given leptin injections X
-Validates the function of leptin, but sidesteps the issue of leptin as a supplement

Leptin in dietary supplement goes in stomach but digestive system break down all proteins in stomach , it means leptin is also broken down. It means it can't reach to blood stream. Thus it can't have any effect.
It strengthens the conclusion.
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I'm super confused now, if "the digestive system breaks down proteins before they can enter the bloodstream", how did it work on the injection for mice ?
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kaomanfen
I'm super confused now, if "the digestive system breaks down proteins before they can enter the bloodstream", how did it work on the injection for mice ?

protein works when given as injection beccause it enters directly in the blood stream( injection is inserted in blood streams) . --> so far so good
but it doesnt work as DIETARTY SUPPLEMENT because
you eat---> digestive system ---> then was supposed to go in blood stream to function properly
A says: it can not reach to blood stream ,
So this protein is useless if directly eaten.

I hope it helps .
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