There are 6 speakers including Alex, Bruno, Carla and Denise. Based on what is given, we know that in the order of speaking
Alex < Bruno < Carla < Denise
Now, total arrangements without any restriction for 6 speakers = 6! = 720
We also know that the 4 speakers above should appear in the exact relative order and not consecutively one after the other which is important to note here
So out of the 4! = 24 relative orders only one is allowed
We also know that, when say k distinct items appear in a fixed relative order
No of arrangements = n! / k!
Similarly,
Required number of arrangements = 6! / 4! = 30D. 30