I am not that smart so here's a simple way that only took me 2 minutes:
x or y have to be less than 20 (20^2 = 400 and that's not in the answer choices).
x and y can't be divisible by 3 so we're left with any of these: 1,2,4,5,7,8,10,11,13,14,16,17,19 as our choices. our answer choices are all in the 333-338 range so we're gonna have to use some big numbers.
Let's run some squares of the big numbers to check whether a smaller square can accompany them:
19 is out since a quicl calculation shows it's above 340.
333-(17^2) = 44.
so 338-(17^2) = 44+5 = 49.
49 is the square of 7, so (17^2) + (7^2) = 338. ANSWER CHOICE E.
Let's run some other numbers just for fun and to see the thought process:
333-(16^2) = 77.
338-(16^2) = 82.
only number in that range that has a square root is 81, but 9 is divisible by 3 so the answer can't be (16^2)+(9^2)
333-(15^2) = 108.
338-(15^2) = 113.
no number has a square root in that range.
333-(14^2) = 137.
338-(14^2) = 142.
no number has a square root in that range.
333-(13^2) = 164.
338-(13^2) = 169.
13 is the square root of 169, so (13^2) + (13^2) = 338, which again shows us ANSWER CHOICE E