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IMO C.

Appositive - an important international issue correctly modifies economic development.
&
"Has worked" is separated by comma, to avoid run on error present in Choice A.
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Since 1945, the United Nations, an organization with 192 member states has worked to promote economic development and it is an important international issue.

(A) states has worked to promote economic development and it is - the words before "has" act as modifier of United nations hence must be separated by commas ; and it is... does not make sense.
(B) states, which has worked to promote economic development, is - illogical construction.
(C) states, has worked to promote economic development, - perfect we have a modifier structure, a proper verb - "has worked" and the last part will act as a modifier to the noun "economic development"
(D) states has worked to promote economic development, being - No comma-ing modifier for a noun. Hence incorrect.
(E) states, has worked to promote economic development, and is - Illogical construction.
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Thank you guys for the discussion.

Kudos to you.

regards
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Since 1945, the United Nations, an organization with 192 member states has worked to promote economic development and it is an important international issue.

(A) states has worked to promote economic development and it is - Missing comma after states to complete the modifier phrase "an organization with 192 member states". A is Out

(B) states, which has worked to promote economic development, is - which is referring to states, which means states has worked to promote development, actually it should be "the United Nations". B is Out

(C) states, has worked to promote economic development, - CORRECT

(D) states has worked to promote economic development, being - Missing comma after states to complete the modifier phrase "an organization with 192 member states". D is Out

(E) states, has worked to promote economic development, and is - usage of "and is" means that "the United Nations" is an important international issue, which is incorrect as it should mean economic development is an important economic issue." E is Out

Hence, Answer is C

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