To find the number of possible combinations of x and y that satisfy the inequality 2 ≤ (1-x)×|y+3| ≤ 5, where x and y are negative integers, we can consider two cases:
Case 1: For -3 ≤ y < 0, we have 2 ≤ (1-x)×(y+3) ≤ 5.
We can solve this inequality for x as follows:
For y = -1, we get 1 ≤ 1-x ≤ 5/2, which simplifies to -3/2 ≤ x ≤ 0, so x = -1 is the only possible value.
For y = -2, we get 2 ≤ 1-x ≤ 5/3, which simplifies to -1/3 ≤ x ≤ 0, so x = -1, -2, -3 are possible values.
Therefore, there are 4 possible combinations of x and y in this case: (-1, -1), (-1, -2), (-2, -2), and (-3, -2).
Case 2: For y ≤ -4, we have 2 ≤ (1-x)×(-y-3) ≤ 5.
We can solve this inequality for x as follows:
For x = -1, we get 2 ≤ -y-3 ≤ -5/2, which simplifies to -1/2 ≤ y ≤ -2, so y = -2, -3, -4, -5 are possible values.
For x = -2, we get 2 ≤ -2y-3 ≤ -5/3, which simplifies to -1/3 ≤ y ≤ -2, so y = -2, -3, -4 are possible values.
For x = -3, we get 2 ≤ -3y-3 ≤ -5/4, which simplifies to -1/4 ≤ y ≤ -2, so y = -2, -3, -4 are possible values.
For x = -4, we get 2 ≤ -4y-3 ≤ -5/5, which simplifies to -1/5 ≤ y ≤ -2, so y = -2, -3, -4 are possible values.
Therefore, there are 12 possible combinations of x and y in this case: (-1, -2), (-1, -3), (-1, -4), (-1, -5), (-2, -2), (-2, -3), (-2, -4), (-3, -2), (-3, -3), (-3, -4), (-4, -2), and (-4, -3).
Combining the two cases, we get a total of 16 possible combinations of x and y. However, since both x and y are negative integers, we need to exclude the combinations where either x or y is not a negative integer. This leaves us with 10 possible combinations:
(-1, -1), (-1, -2), (-2, -2), (-3, -2), (-4, -2) from Case 1
(-1, -2), (-1, -3), (-1, -4), (-1, -5), (-2, -2), (-2, -3), (-2, -4), (-3, -2), (-3, -3), (-3, -4), (-4, -2), and (-4, -3) from Case 2
Therefore, there are 10 possible combinations of x and y that satisfy the given inequality. The answer is E) 10.